Keloids - The sebum hypothesis revisited

Medical Hypotheses

Volumn 58, Issue 4, 2002, Pages 264-269

  Fong, E P ^a   Bay, B H ^b  

^a UNIVERSITY MALAYA MEDICAL CENTRE   (Malaysia)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; CORTICOSTEROID DERIVATIVE; AUTOANTIGEN;

ADULT; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; CASE REPORT; CELL COUNT; CELL TYPE; CELLULAR IMMUNITY; CLINICAL FEATURE; CLONAL ANERGY; CONTROLLED STUDY; CYTOLOGY; DELAYED HYPERSENSITIVITY; DISEASE COURSE; ELECTRON MICROSCOPY; FEMALE; HELPER CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYPOTHESIS; IMAGE ANALYSIS; IMMUNE SYSTEM; IMMUNOLOGICAL TOLERANCE; KELOID; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MALE; MAST CELL; PHAGOCYTOSIS; PRIORITY JOURNAL; SCHOOL CHILD; SEBUM; STIMULUS RESPONSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; ADOLESCENT; AGED; BIOLOGICAL MODEL; CHILD; IMMUNOLOGY; INJURY; METABOLISM; MIDDLE AGED; PATHOLOGY; POSTOPERATIVE COMPLICATION; SEBACEOUS GLAND; SECRETION; SKIN; T LYMPHOCYTE SUBPOPULATION; TATTOOING; ULTRASTRUCTURE; VACCINATION;

ADOLESCENT; ADULT; AGED; AUTOANTIGENS; CHILD; COLLAGEN; FEMALE; HUMANS; HYPERSENSITIVITY, DELAYED; KELOID; MALE; MICROSCOPY, ELECTRON; MIDDLE AGED; MODELS, BIOLOGICAL; POSTOPERATIVE COMPLICATIONS; SEBACEOUS GLANDS; SEBUM; SKIN; T-LYMPHOCYTE SUBSETS; TATTOOING; VACCINATION;

EID: 0035996659     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.2001.1426     Document Type: Article

References (37)

1. Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-b
2. Transforming growth factor-b increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts
3. Control of scarring in adult wounds by neutralising antibody to transforming growth factor-b
4. Independent regulation of collagenase, 72 kDa-progelatinase and metalloproteinase inhibitor (TIMP) expression in human fibroblasts by transforming growth factor-b
5. Transforming growth factor-beta in human platelets
6. Purification and initial characterization of a type beta transforming growth factor from human placenta
7. Activation of collagen gene expression in keloids: Co-localization of type I and VI collagen and transforming growth factor-beta I mRNA
8. Hypertrophic scars
9. Does an immune reaction to sebum in wounds cause keloid scars? Beneficial effect of desensitisation
10. Hypertrophic scars
11. Treatment of keloids
12. The management of scars, hypertrophic scars and keloids
13. Anaerobic metabolism and wound healing: An hypothesis for the initiation and cessation of collagen synthesis in wounds
14. Perivascular myofibroblast and microvascular occlusion in hypertrophic scars and keloids
15. Elevated collagen synthesis in cultured keloid fibroblasts
16. Biochemical composition of the connective tissue in keloids and analysis of collagen metabolism in keloid fibroblast cultures
17. Cell size and growth characteristics of cultured fibroblasts isolated from normal and keloid tissue
18. Collagen gene expression in keloids: Analysis of collagen metabolism and type I, III, IV and V procollagen mRNAs in keloid tissue and keloid fibroblast cultures
19. Variability in collagen and fibronectin synthesis by scleroderma fibroblasts in primary culture
20. Histamine and collagen synthesis in keloid and hypertrophic scar
21. The effect of histamine on the growth of cultured fibroblasts isolated from normal and keloid tissue
22. Tissue mast cells in keloidal scars
23. The possible role of mast cells (allergy) in the production of keloid and hypertrophic scarring
24. Mast cell granules cause proliferation of human microvascular endothelial cells
25. Keloids in the African
26. Immunoglobulin, complement, and histocompatibility Ag studies in keloid patients
27. Immunoglobulin in hypertrophic scars and keloids
28. Location of androgen receptor in human skin
29. Pilosebaceous duct physiology. III. Observations on the number and size of pilosebaceous ducts in acne vulgaris
30. The role of lymphocytes in wound healing
31. Apoptosis, necrosis and proliferation. Possible implications in the etiology of keloids
32. Effector mechanism of T-cell-mediated immune response
33. Superficial radiotherapy in acne vulgaris
34. Control and function of sebaceous glands
35. A modification of Jerne's theory of antibody production using the concept of clonal selection
36. Immunological investigations in post-traumatic granulomatous and non-granulomatous uveitis
37. Autoimmune orchitis, epididymitis and vasitis are immunogenetically distinct lesions