Toxicity of cylindrospermopsin to the brine shrimp Artemia salina: Comparisons with protein synthesis inhibitors and microcystins

Toxicon

Volumn 40, Issue 8, 2002, Pages 1115-1120

  Metcalf, J S ^a   Lindsay, J ^a   Beattie, K A ^a   Birmingham, S ^a   Saker, M L ^b   Torokne A K ^c   Codd, G A ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b Inst de Zoologia Dr Augusto Nobre   (Portugal)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH   (Hungary)

Author keywords

Artemia; Cyanobacteria; Cylindrospermopsin; Cylindrospermopsis; Microcystin

Indexed keywords

CHLORAMPHENICOL; CYANOGINOSIN LR; CYCLOHEXIMIDE; CYLINDROSPERMOPSIN; PROTEIN SYNTHESIS INHIBITOR; TETRACYCLINE; CYANOGINOSIN; CYCLOPEPTIDE; DRUG DERIVATIVE; URACIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTEMIA; ARTICLE; BACTERIAL STRAIN; BIOASSAY; CONTROLLED STUDY; CYANOBACTERIUM; CYCLINDROSPERMOPSIS RACIBORSKII; DOSE RESPONSE; GRAVIMETRY; LC 50; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; TOXICITY; ANIMAL; CHEMISTRY; COMPARATIVE STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; LD 50; METABOLISM; PHYSIOLOGY;

ANIMAL; ARTEMIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPARATIVE STUDY; CYANOBACTERIA; DOSE-RESPONSE RELATIONSHIP, DRUG; LETHAL DOSE 50; PEPTIDES, CYCLIC; PROTEIN SYNTHESIS INHIBITORS; SUPPORT, NON-U.S. GOV'T; URACIL; ANIMALS; MICROCYSTINS;

ANOSTRACA; ARTEMIA; ARTEMIA SALINA; CYANOBACTERIA; CYLINDROSPERMOPSIS; CYLINDROSPERMOPSIS RACIBORSKII; DECAPODA (CRUSTACEA); SALINA;

EID: 0035993533     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(02)00105-8     Document Type: Article

References (29)

1. Identification of cylindrospermopsin in Aphanizomenon ovalisporum (Cyanophyceae) isolated from Lake Kinneret
2. 7-epicylindrospermopsin, a toxic minor metabolite of the cyanobacterium Aphanizomenon ovalisporum from Lake Kinneret, Israel
3. Uracil moiety is required for toxicity of the cyanobacterial hepatotoxin cylindrospermopsin
4. An outbreak of hepato-enteritis (the Palm Island mystery disease) possibly caused by algal intoxication
5. Palm Island mystery disease
6. Comparative assessment of the specificity of the brine shrimp and Microtox assays to hepatotoxic (microcystin-LR containing) cyanobacteria
7. Toxicity and uptake mechanism of cylindrospermopsin and lophyrotomin in primary rat hepatocytes
8. Cyanobacterial toxins, exposure routes and human health
9. Use of HPLC-MS/MS to monitor cylindrospermopsin, a blue-green algal toxin for public health purposes
10. Cell-free protein synthesis inhibition assay for the cyanobacterial toxin cylindrospermopsin
11. Isolation of cylindrospermopsin from a cyanobacterium Umezakia natans and its screening method
12. Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir
13. Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake
14. Detection of toxicity of cyanobacteria by Artemia salina bioassay
15. Extraction and high-performance liquid chromatographic method for the determination of microcystins in raw and treated waters
16. Effects of solvent conditions on the recovery, purification and analysis of cylindrospermopsin from Cylindrospermopsis raciborskii
17. Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii
18. Cylindrospermopsin - A potent hepatotoxin from the blue-green-alga Cylindrospermopsis raciborskii
19. The accumulation of cylindrospermopsin from the cyanobacterium Cylindrospermopsis raciborskii in tissues of the Redclaw crayfish, Cherax quadricarinatus
20. Varied diazotrophies, morphologies and toxicities of genetically similar isolates of Cylindrospermopsis raciborskii (Nostocales, Cyanophyceae) from Northern Australia
21. Cattle mortality attributed to the toxic cyanobacterium Cylindrospermopsis raciborskii in an outback region of North Queensland
22. The oral toxicity for mice of the tropical cyanobacterium Cylindrospermopsis raciborskii (Woloszynska)
23. Blooms of the cylindrospermopsin containing cyanobacterium, Aphanizomenon ovalisporum (Forti), in newly constructed lakes, Queensland, Australia
24. Cylindrospermopsin, a cyanobacterial alkaloid: Evaluation of its toxicologic activity
25. Cyanobacterial toxins
26. Purification and properties of unicellular blue-green algae (order Chroococcales)
27. Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from the blue-green alga Umezakia natans
28. A new culture-free microbiotest for routine detection of cyanobacterial toxins
29. Protracted toxic effects caused by saline extracts of Aphanizomenon flos-aquae (Cyanophyceae/Cyanobacteria)