Microscopic kinetics and structure-function analysis in the vesicular acetylcholine transporter

Neurochemistry International

Volumn 41, Issue 5, 2002, Pages 285-289

  Bravo, Dawn ^a   Parsons, Stanley M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Microscopic kinetics; Rate constant; Vesicular acetylcholine transporter

Indexed keywords

ACETYLCHOLINE; MUTANT PROTEIN; VESICULAR ACETYLCHOLINE TRANSPORTER; CARRIER PROTEIN; SLC18A3 PROTEIN, HUMAN; VESICULAR TRANSPORT PROTEIN;

ACETYLCHOLINE RELEASE; ARTICLE; BINDING SITE; CHOLINERGIC NERVE; EXPERIMENTAL MODEL; HUMAN; KINETICS; MATHEMATICAL MODEL; MUTATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANIMAL; BIOLOGICAL MODEL; GENETICS; METABOLISM; PHYSIOLOGY; REVIEW;

ANIMAL; CARRIER PROTEINS; HUMAN; KINETICS; MODELS, BIOLOGICAL; MUTATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; HUMANS; MEMBRANE TRANSPORT PROTEINS; VESICULAR ACETYLCHOLINE TRANSPORT PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 0035993229     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(02)00058-X     Document Type: Article

References (20)

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4. A critical histidine in the vesicular acetylcholine transporter
5. Modification of cysteines reveals linkage relationships among acetylcholine and vesamicol binding sites in the vesicular acetylcholine transporter of Torpedo californica
6. Mutational analysis of aspartate residues in the transmembrane regions and cytoplasmic loops of rat vesicular acetylcholine transporter
7. Mutational analysis of basic residues in the rat vesicular acetylcholine transporter. Identification of a transmembrane ion pair and evidence that histidine is not involved in proton translocation
8. Isolation and characterization of mutants for the vesicular acetylcholine transporter gene in Drosophila melanogaster
9. Charged residues in transmembrane domains II and XI of a vesicular monoamine transporter form a charge pair that promotes high affinity substrate recognition
10. Kinetics parameters for the vesicular acetylcholine transporter: Two protons exchange for one acetylcholine
11. Transport mechanisms in acetylcholine and monoamine storage
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13. Vesicular neurotransmitter transport and the presynaptic regulation of quantal size
14. Expression of a putative vesicular acetylcholine transporter facilitates quantal transmitter packaging
15. Modification of the pH profile and tetrabenazine sensitivity of rat VMAT1 by replacement of aspartate 404 with glutamate
16. Regulation of quantal size by presynaptic mechanisms
17. The regulation of quantal size
18. Vesicular neurotransmitter transporters. Potential sites for the regulation of synaptic function
19. Dissociation of the vesicular acetylcholine transporter domains important for high-affinity transport recognition, binding of vesamicol and targeting to synaptic vesicles
20. How does a vesicle know it is full?