3-hydroxy-3-methylglutaryl coenzyme A reductase activity and low-density lipoprotein receptor expression in diffuse-type and intestinal-type human gastric cancer

Journal of Gastroenterology

Volumn 37, Issue 7, 2002, Pages 504-508

  Caruso, Maria Gabrielle ^a   Notarnicola, Maria ^a   Cavallini, Aldo ^a   Di Leo, Alfredo ^a  

^a NATIONAL INSTITUTE FOR DIGESTIVE DISEASES   (Italy)

Author keywords

Diffuse type GC; HMGCoAR; Intestinal type GC; LDLR

Indexed keywords

CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER TISSUE; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOMETRY; STOMACH ADENOCARCINOMA; STOMACH MUCOSA; METABOLISM; MIDDLE AGED; STOMACH TUMOR;

AGED; CHOLESTEROL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTRIC MUCOSA; HUMAN; HYDROXYMETHYLGLUTARYL COA REDUCTASES; MALE; MIDDLE AGE; RECEPTORS, LDL; STOMACH NEOPLASMS; HUMANS; MIDDLE AGED;

EID: 0035992581     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005350200078     Document Type: Article

References (32)

1. Estimates of worldwide incidence of 18 major cancers in 1985
2. Adenocarcinoma of the stomach: Are we making progress?
3. Human gastric carcinogenesis: A multistep and multifactorial process
4. Gastric carcinoma
5. The two histological main types of gastric carcinoma-diffuse and so-called intestinal type carcinoma
6. Molecular biology and gastric carcinoma
7. Genetic alterations in gastric cancer: Relation to histological subtypes, tumour stage and Helicobacter pylori infection
8. Molecular biology of gastric carcinoma: From laboratory to bedside
9. Polyamine levels and ODC activity in intestinal-type and diffuse-type gastric carcinoma
10. The significance of the cholesterol pathway in cell growth and carcinogenesis
11. 3-Hydroxy-3-methylglutaryl coenzyme A reductase in human brain tumours
12. Low density lipoprotein receptor-binding activity in human tissues: Quantitative importance of hepatic receptors and evidence for regulation of their expression in vivo
13. Geshwulste des Magens und Duodenums
14. Enhanced 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human colorectal cancer not expressing low density lipoprotein receptor
15. A simplified immunoenzymetric assay of the epidermal growth factor in breast tumors: Evaluation in 282 cases
16. Protein measurement with the Folin phenol reagent
17. Demonstration of low density lipoprotein receptor in human colonic carcinoma and surrounding mucosa by immunoenzymatic assay
18. Low density lipoprotein receptor activity in human intracranial tumors and its relation to the cholesterol requirement
19. Abnormal cholesterol metabolism in renal clear cell carcinoma
20. Increase in the active form of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human hepatocellular carcinoma: Possible mechanism for alteration of cholesterol biosynthesis
21. In vivo regulation of human leucocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase: Increased enzyme protein concentration and catalytic efficiency in human leukemia and lymphoma
22. Low density lipoprotein receptor and polyamine levels in human colorectal adenocarcinoma
23. Increased LDL receptor mRNA expression in colon cancer is correlated with a rise in plasma cholesterol levels after curative surgery
24. Expression of the low density lipoprotein receptor, HMG-CoA reductase and multidrug resistance (Mdr 1) genes in colorectal carcinoma
25. Low density lipoprotein receptor and its mRNA expression in human colorectal carcinoma
26. Intestinal metaplasia subtypes and cancer risk
27. Delivery of aclacinomycin A to human glioma cells in vitro by the low density lipoprotein pathway
28. Preparation of drug-low density lipoprotein complexes for delivery of antitumoral drugs via mevinolin, a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase
29. Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase
30. Inhibition of pancreatic adenocarcinoma cell growth by lovastatin
31. Phase I study of lovastatin, an inhibitor of mevalonate pathway in patients with cancer
32. Effect of pravastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, on two human tumour cell lines