Hypoxia modifies proliferation and differentiation of CD34+ CML cells

Stem Cells

Volumn 20, Issue 4, 2002, Pages 347-354

  Desplat, Vanessa ^a   Faucher, Jean Luc ^b   Mahon, François Xavier ^a   Sbarba, Persio Dello ^c   Praloran, Vincent ^a   Ivanovic, Zoran ^a,d  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b LIMOGES UNIVERSITY HOSPITAL   (France)

^c UNIVERSITY OF FLORENCE   (Italy)

^d Lab d'Hematologie Pharmaceut   (France)

Author keywords

CD34+ cells; CML cells; Differentiation; Hypoxia; PAF R

Indexed keywords

CD34 ANTIGEN; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; CELL SURFACE RECEPTOR; FIBRINOGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; TYROSINE;

APHERESIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL POPULATION; CELL PROLIFERATION; CELL SURFACE; CHRONIC MYELOID LEUKEMIA; COLONY FORMING UNIT; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HYPOXIA; INCUBATION TIME; PHENOTYPE; PROTEIN PHOSPHORYLATION; STEM CELL; CANCER STEM CELL; CELL DIVISION; CELL HYPOXIA; CELL MEMBRANE; CELL SURVIVAL; CYTOLOGY; DOWN REGULATION; GENE EXPRESSION; METABOLISM; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY;

MURINAE;

ANTIGENS, CD34; CELL DIFFERENTIATION; CELL DIVISION; CELL HYPOXIA; CELL MEMBRANE; CELL SURVIVAL; DOWN-REGULATION; GENE EXPRESSION; HUMANS; LEUKEMIA, MYELOID, CHRONIC; PHOSPHORYLATION; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; TUMOR CELLS, CULTURED; TUMOR STEM CELLS; TYROSINE;

EID: 0035991660     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.20-4-347     Document Type: Article

References (19)

1. Primitive human HPCs are better maintained and expanded in vitro at 1 percent oxygen than at 20 percent
2. + murine bone marrow cells
3. Hemopoietic progenitor cells are sensitive to the cytostatic effect of pyruvate
4. + progenitors
5. Platelet-activating factor receptor
6. Two different promoters direct expression of two distinct forms of mRNAs of human platelet-activating factor receptor
7. Expression of platelet-activating factor receptor transcript-1 but not transcript-2 by human bone marrow cells
8. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
9. The molecular biology of chronic myeloid leukemia
10. Spontaneous and inducible production of macrophage colony-stimulating factor by human bone marrow stromal cells
11. Evaluation of ex vivo expansion potential of cord blood and bone marrow hematopoietic progenitor cells using cell tracking and limiting dilution analysis
12. Incubation of murine bone marrow cells in hypoxia ensures the maintenance of marrow-repopulating ability together with the expansion of committed progenitors
13. The expansion of murine bone marrow cells preincubated in hypoxia as an in vitro indicator of their marrow-repopulating ability
14. Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: Diverse mechanisms of resistance
15. Chronic myelogenous leukemia primitive hematopoietic progenitors demonstrate increased sensitivity to growth factor-induced proliferation and maturation
16. The role of hypoxia in the maintenance of hematopoietic stem cells
17. Reduction of tyrosine kinase activity and protein tyrosine dephosphorylation by anoxic stimulation in vitro
18. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity
19. ERK activation upon hypoxia: Involvement in HIF-1 activation