Saquinavir soft-gel capsules (Fortovase®) give lower exposure than expected, even after a high-fat breakfast

Pharmacy World and Science

Volumn 24, Issue 3, 2002, Pages 83-86

  Hugen, P W H ^a,b   Burger, D M ^a,b   Koopmans, P P ^a,b   Cohen Stuart, J W T ^c   Kroon, F P ^d   Van Leusen, R ^e   Hekster, Y A ^e  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b University Medical Centre Utrecht ^*

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e RIJNSTATE HOSPITAL   (Netherlands)

Author keywords

Food; Grapefruit juice; Pharmacokinetics; Saquinavir

Indexed keywords

RITONAVIR; SAQUINAVIR;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; EXPOSURE; FAT INTAKE; GRAPEFRUIT JUICE; HUMAN; MALE; MEAL; BLOOD; CHEMISTRY; COMPARATIVE STUDY; FOOD DRUG INTERACTION; MICROCAPSULE; MIDDLE AGED; NONPARAMETRIC TEST;

ADULT; AREA UNDER CURVE; CAPSULES; CHEMISTRY, PHARMACEUTICAL; COMPARATIVE STUDY; DIETARY FATS; FOOD-DRUG INTERACTIONS; HUMAN; MALE; MIDDLE AGE; SAQUINAVIR; STATISTICS, NONPARAMETRIC; HUMANS; MIDDLE AGED;

EID: 0035990403     PISSN: 09281231     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016121100568     Document Type: Article

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