Immunohistological analysis of CD59 and membrane attack complex of complement in muscle in juvenile dermatomyositis

Journal of Rheumatology

Volumn 29, Issue 6, 2002, Pages 1301-1307

  Gonçalves, Flávia G P ^a   Chimelli, Leila ^a   Sallum, Adriana M E ^a   Marie, Suely K N ^a   Kiss, Maria Helena B ^a   Ferriani, Virgínia P L ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

CD59; Complement; Juvenile dermatomyositis; Membrane attack complex; Muscular dystrophy

Indexed keywords

CD59 ANTIGEN; COMPLEMENT MEMBRANE ATTACK COMPLEX; BIOLOGICAL MARKER;

ANTIGEN DETECTION; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DERMATOMYOSITIS; ENDOTHELIUM; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; IMMUNOREACTIVITY; MALE; MUSCLE BIOPSY; MUSCLE CELL; MUSCULAR DYSTROPHY; PRIORITY JOURNAL; SARCOLEMMA; SKELETAL MUSCLE; COMPARATIVE STUDY; CULTURE TECHNIQUE; HOSPITALIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; NEEDLE BIOPSY; PATHOLOGY; PRESCHOOL CHILD; PROGNOSIS; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY;

ANTIGENS, CD59; BIOLOGICAL MARKERS; BIOPSY, NEEDLE; CHILD; CHILD, PRESCHOOL; COMPARATIVE STUDY; COMPLEMENT MEMBRANE ATTACK COMPLEX; DERMATOMYOSITIS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE, SKELETAL; MUSCULAR DYSTROPHIES; PROGNOSIS; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX; TISSUE CULTURE; CULTURE TECHNIQUES; HUMANS;

EID: 0035990331     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Juvenile dermatomyositis
2. Dermatomyositis (systemic angiopathy) of childhood
3. Microvascular deposition of complement membrane attack complex in dermatomyositis
4. Microvascular changes in early and advanced dermatomyositis: A quantitative study
5. High dose intravenous immunoglobulin exerts its beneficial effect in patients with dermatomyositis by blocking endomysial deposition of activated complement fragments
6. CD59, an Ly-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells
7. Human protectin (CD59), an 18,000-20,000 MW complement lysis restricting factor, inhibits C5b-8 catalysed insertion of C9 into lipid bilayers
8. The complement-inhibitory activity of CD59 resides in its capacity to block incorporation of CD59 into C5b-9
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10. Regulatory control of complement on blood platelets
11. CD59 expressed by human endothelial cells as a protective molecule against complement lysis
12. Tissue distribution of HRF20, a novel factor preventing the membrane attack of homologous complement, and its predominant expression on endothelial cells in vivo
13. The complement-inhibiting protein, protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells
14. Characterisation of homologous restriction factor (HRF-20) in human skin and leukocytes
15. Complement regulatory proteins at the feto-maternal interface during human placental development: Distribution of CD59 by comparison with membrane cofactor protein (CD46) and decay accelerating factor (CD55)
16. Membrane attack complex (MAC)-mediated damage to spermatozoa: Protection of the cells by the presence on their membranes of MAC inhibitory proteins
17. Distribution of protectin (CD59), a complement membrane attack inhibitor, in normal human tissues
18. Anti-thyroid drugs and release of inflammatory mediators by complement-attached thyroid cells
19. Differential expression of the complement regulatory proteins in the human eye
20. Expression of CD59, a regulator of the membrane attack complex of complement, on human skeletal muscle fibers
21. Loss of expression of protectin (CD59) is associated with complement membrane attack complex deposition in myocardial infarction
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24. Human skeletal myoblasts spontaneously activate allogenic complement but are resistant to killing
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27. The relationship of complement-mediated microvasculopathy to the histologic features and clinical duration of disease in dermatomyositis
28. Detection of a soluble form of the complement membrane attack complex inhibitor CD59 in plasma after acute myocardial infarction