Hyperosmolality induced by betaine or urea stimulates endothelin synthesis by differential activation of ERK and p38 MAP kinase in MDCK cells

Kidney and Blood Pressure Research

Volumn 25, Issue 2, 2002, Pages 65-70

  Kramer, Herbert J ^a,b   Hashemi, T ^a   Backer A ^a   Bokemeyer, D ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Betaine; ET synthesis; MAP kinases; MDCK cells; Osmotic stress; Urea

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ARGIPRESSIN; BETAINE; CYCLIC AMP; ENDOTHELIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SODIUM CHLORIDE; SYNAPTOPHYSIN; UREA; ENDOTHELIN 1; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE 1;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL STRAIN; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC POTENTIAL; ENZYME ACTIVATION; HYPEROSMOLALITY; IN VIVO STUDY; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; STRESS; ANIMAL; BIOSYNTHESIS; DOG; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EXTRACELLULAR SPACE; METABOLISM; OSMOLARITY; TIME;

ANIMALS; BETAINE; DOGS; ENDOTHELIN-1; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SPACE; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASES; OSMOLAR CONCENTRATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TIME FACTORS; UREA;

EID: 0035988401     PISSN: 14204096     EISSN: None     Source Type: Journal    
DOI: 10.1159/000063510     Document Type: Article

References (26)

1. Characteristics of endothelin receptors and intracellular signalling in porcine inner medullary collecting duct cells
2. Endothelin inhibits vasopressin-stimulated water permeability in rat terminal inner medullary collecting duct
3. Endothelin-1 inhibits AVP-stimulated osmotic water permeability in rat inner medullary collecting duct
4. Endothelin synthesis by porcine inner medullary collecting duct cells
5. Hyper-osmolality regulates endothelin release by Madin-Darby canine kidney cells
6. Osmolar regulation of endothelin-1 production by rat inner medullary collecting duct
7. Effect of hyperosmolality on production and mRNA expression of ET-1 in inner medullary collecting duct
8. Rat renal, aortic and pulmonary endothelin-1 receptors: Effects of changes in sodium and water intake
9. Effects of ET-1 on water and chloride transport in cortical collecting ducts in the rat
10. Regulation of cortical collecting duct function: Effect of endothelin
11. i in M-1 mouse cortical collecting duct cells by a dual mechanism
12. Cellular response to osmotic stress in the renal medulla
13. Multiple mitogen-activated protein kinases are regulated by hyperosmolality in mouse IMCD cells
14. ERK activation of urea in the renal inner medullary mIMCD3 cell line
15. p38 kinase activity is essential for osmotic induction of mRNAs for HSP70 and transporter for organic solute betaine in Madin-Darby canine kidney cells
16. Regulation of mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle cells
17. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stress and interleukin-1
18. Identification of a novel inhibitor of mitogen-activated protein kinase
19. Induction of water diuresis by endothelin in rats
20. Intrazelluläre signal-transduktion durch mitogen-aktivierte proteinkinasen
21. Die rolle mitogen-aktivierter protein (MAP)-Kinasen bei der osmotischen stimulation der endothelinsynthese innermedullärer sammelrohrzellen der nieren
22. PreproEndothelin expression in human mesangial cells: Evidence for a p38 mitogen-activated protein kinase/protein kinases-C-dependent mechanism
23. - dependent betaine transporter in Madin-Darby canine kidney cells by increasing transcription of the transporter gene
24. + myo-inositol co-transporter in MDCK cells
25. Urea transporters in kidney: Molecular analysis and contribution to the urinary concentrating process
26. Differential regulation of renal regional blood flow by endothelin-1