Lack of evidence for a significant association between nonsyndromic cleft lip with or without cleft palate and the retinoic acid receptor alpha gene in the Japanese population

Journal of Human Genetics

Volumn 47, Issue 6, 2002, Pages 269-274

  Kanno, K ^a   Suzuki, Y ^a   Yang, X ^a   Yamada, A ^a   Aoki, Y ^a   Kure, S ^a   Matsubara, Y ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Denaturing high performance liquid chromatography; Microsatellite marker; Nonsyndromic cleft lip with or without cleft palate; Polymorphism; Retinoic acid; Retinoic acid receptor alpha; Transmission disequilibrium test

Indexed keywords

RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; DNA; MICROSATELLITE DNA; PRIMER DNA; RETINOIC ACID RECEPTOR; THYMIDINE;

ADULT; ALLELE; ARTICLE; CLEFT LIP; CLEFT LIP PALATE; CLINICAL ARTICLE; DNA DETERMINATION; DNA POLYMORPHISM; ENVIRONMENTAL FACTOR; EXON; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; HEREDITY; HUMAN; HUMAN CELL; JAPAN; MICROSATELLITE MARKER; NUCLEIC ACID BASE SUBSTITUTION; PATHOGENESIS; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; CHEMISTRY; CLEFT PALATE; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; POLYMERASE CHAIN REACTION; POPULATION GENETICS; QUANTITATIVE TRAIT;

ALLELES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLEFT LIP; CLEFT PALATE; DNA; DNA PRIMERS; EXONS; GENETICS, POPULATION; GENOTYPE; HUMAN; JAPAN; LINKAGE DISEQUILIBRIUM; MICROSATELLITE REPEATS; POLYMERASE CHAIN REACTION; QUANTITATIVE TRAIT, HERITABLE; RECEPTORS, RETINOIC ACID; SUPPORT, NON-U.S. GOV'T; THYMIDINE; VARIATION (GENETICS); HUMANS;

EID: 0035986997     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380200038     Document Type: Article

References (10)

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4. Hypervitaminosis A induced teratogenesis
5. Application of transmission disequilibrium tests to nonsyndromic oral clefts: Including candidate genes and environmental exposures in the models
6. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci
7. Further evidence of a relationship between the retinoic acid receptor alpha locus and nonsyndromic cleft lip with or without cleft palate (CL +/- P)
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9. Genetics of nonsyndromic oral clefts revisited
10. A program for the monte carlo evaluation of significance of the extended transmission/disequilibrium test