Analysis of the mutations in the active site of the RNA-dependent RNA polymerase of human parainfluenza virus type 3 (HPIV3)

Gene Expression

Volumn 10, Issue 3, 2002, Pages 93-100

  Malur, Achut G ^a   Gupta, Neera K ^a   De, Bishnu P ^a   Banerjee, Amiya K ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Human parainfluenza virus type 3 (HPIV3); In vitro transcription; Mutagenesis; RNA dependent RNA polymerase

Indexed keywords

GLYCINE CLEAVAGE SYSTEM; MUTANT PROTEIN; RNA DIRECTED RNA POLYMERASE; VIRUS MESSENGER RNA; MESSENGER RNA; VIRUS DNA; VIRUS RNA;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE MUTATION; GENE REPLICATION; IN VIVO STUDY; NONHUMAN; PARAINFLUENZA VIRUS 3; PROTEIN DOMAIN; PROTEIN MOTIF; RNA TRANSCRIPTION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION; WILD TYPE; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; HELA CELL; HUMAN; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; VIRUS GENE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CATALYTIC DOMAIN; CONSERVED SEQUENCE; DNA, VIRAL; GENES, VIRAL; HELA CELLS; HUMAN; MUTAGENESIS, SITE-DIRECTED; MUTATION; PARAINFLUENZA VIRUS 3, HUMAN; RNA REPLICASE; RNA, MESSENGER; RNA, VIRAL; SUPPORT, U.S. GOV'T, P.H.S.; HUMANS;

HUMAN PARAINFLUENZA VIRUS 3; RNA VIRUSES;

EID: 0035986838     PISSN: 10522166     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: A two metal ion mechanism
2. Mutational analysis of the conserved motifs of influenza A virus polymerase basic protein 1
3. Measles virus L protein evidences elements of ancestral RNA polymerase
4. Parainfluenza viruses
5. Molecular cloning and complete nucleotide sequence of the attenuated rabies virus SAD B19
6. An acidic activation-like domain of the Sendai virus P protein is required for RNA synthesis and encapsidation
7. Human parainfluenza virus type 3 transcription in vitro: Role of cellular actin in mRNA synthesis
8. Role of cellular actin in human parainfluenza virus type 3 genome transcription
9. Role of the NH2-and COOH-terminal domains of the P protein of human parainfluenza virus type 3 in transcription and replication
10. Molecular cloning and sequence analysis of the human parainfluenza 3 virus gene encoding the L protein
11. Precise mapping of the replication and transcription promoters of human parainfluenza virus type 3
12. Interference with viral replication by defective RNA replicase
13. Enzymatic activity of polio virus RNA polymerase mutants with single amino acid changes in the conserved YGDD amino acid motif
14. Enzymatic activity of polio virus RNA polymerase with mutations at the tyrosine residue of the conserved YGDD motif: Isolation and characterization of polio viruses containing RNA polymerases with FGDD and MGDD sequences
15. Mutagenesis of the L protein encoded by Bunyamwera virus and production of monospecific antibodies
16. Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complex with an inhibitor
17. Site-specific mutagenesis of AIDS virus reverse transcriptase
18. Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity
19. Identification and characterization of the Escherichia coli-expressed RNA-dependent RNA polymerase of bamboo mosaic virus
20. Rift valley fever virus L segment: Correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerases
21. Molecular cloning and sequence analysis of the mumps virus gene encoding the L protein and the trailer sequence
22. Identification of four conserved motifs among RNA-dependent polymerase encoding elements
23. Sequence comparison of five polymerases (L proteins) of unsegmented negative-strand RNA viruses; theoretical assignment of functional domains
24. Molecular cloning of the NP and L genes of simian virus 5: Identification of highly conserved domains in paramyxovirus NP and L proteins
25. Polymerase activity of in vitro mutated rabies virus L protein
26. Primary structure of the vesicular stomatitis virus polymerase (L) gene: Evidence for a high frequency of mutations
27. Determination of the complete nucleotide sequence of the Sendai virus genome RNA and the predicted amino acid sequences of the F, HN and L proteins
28. Canine distemper virus L gene: Sequence and comparison with related viruses
29. Transcriptional activity and mutational analysis of recombinant vesicular stomatitis virus RNA polymerase
30. Mutation analysis of the GDD sequence motif of a calcivirus RNA-dependent RNA polymerase
31. Nucleotide sequence analysis of the L gene of Newcastle disease virus: Homologies with Sendai and vesicular stomatitis viruses