Pharmacokinetic and pharmacodynamic evaluation of cyclosporin A O/W-emulsion and microsphere formulations in rabbits

European Journal of Pharmaceutical Sciences

Volumn 15, Issue 5, 2002, Pages 497-502

  Kim, Soo Jin ^a   Choi, Hoo Kyun ^b   Suh, Soon Pal ^a   Lee, Yong Bok ^a  

^a Chonnam National University   (South Korea)

^b Chosun University   (South Korea)

Author keywords

Cyclosporin A; Microsphere; O W emulsion; Pharmacodynamics; Pharmacokinetics

Indexed keywords

BLOOD; EMULSIONS;

COMMERCIAL PRODUCTS;

PHARMACOKINETICS;

CIPOL INJ.; CYCLOSPORIN A; MICROSPHERE; UNCLASSIFIED DRUG; CYCLOSPORIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG FORMULATION; LYMPHOCYTE SUBPOPULATION; MALE; MICROEMULSION; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; PHARMACOKINETICS; PRIORITY JOURNAL; RABBIT; ANIMAL; AREA UNDER THE CURVE; BLOOD; CHEMISTRY; EMULSION; EVALUATION;

ANIMAL; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CYCLOSPORINE; EMULSIONS; MALE; MICROSPHERES; RABBITS; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0035984944     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00048-9     Document Type: Article

References (25)

1. Assessment of cyclosporin A in whole blood and plasma in five patients with different hematocrits
2. Oral administration of liposomes containing cyclosporine: a pharmacokinetic study
3. Pharmacodynamic monitoring of cyclosporin
4. Use of the isolated perfused kidney model to assess the acute pharmacologic effects of cyclosporine and its vehicle, Cremophor EL
5. Formulation of dosage forms
6. Comparison of four basic models of indirect pharmacodynamic responses
7. Effect of acetazolamide on the pharmacokinetics of cyclosporin in rabbits
8. Cyclosporine neurotoxicity: a review
9. Role of dosage regimen in controlling indirect pharmacodynamic response
10. Cyclosporine: a revolution in transplantation
11. Pharmacokinetics and organ distribution of cyclosporin A incorporated in liposomes and mixed micelles
12. Effect of adding non-volatile oil as a core material for the floating microspheres prepared by emulsion solvent diffusion method
13. Performance of sonication and microfluidization for liquid-liquid emulsification
14. Chronopharmacokinetics of cyclosporine A following a single i.v. dose in the Wistar rat
15. ®)
16. Using microemulsion formulations for oral drug delivery of therapeutic peptides
17. Dissolving intravenous cyclosporin A in a fat emulsion carrier prevents acute renal side effects in the rat
18. Cyclosporin A in fat emulsion carriers: experimental studies on pharmacokinetics and tissue distribution
19. Cyclosporin A in fat emulsion carrier: studies on the immunosuppressive potential, using the heterotopic heart transplant model in rats
20. Modification of release rates of cyclosporin A from poly (L-lactic acid) microspheres by fatty acid esters and in-vivo evaluation of the microspheres
21. Pharmacokinetic and pharmacodynamic evaluation of liposomal cyclosporine