MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes

EMBO Reports

Volumn 3, Issue 5, 2002, Pages 463-470

  El Amraoui, Aziz ^a   Schonn, Jean Sébastien ^a   Küssel Andermann, Polonca ^a   Blanchard, Stéphane ^b   Desnos, Claire ^c   Henry, Jean Pierre ^d   Wolfrum, Uwe ^e   Darchen, François ^e   Petit, Christine ^f  

^a DIVISION OF REPRODUCTIVE BIOLOGY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

^c RESEARCH AND DEVELOPMENT   (Australia)

^d College of Chemistry and Molecular Engineering ^*  (China)

^e UNIVERSITY OF SHEFFIELD   (United Kingdom)

^f INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BRIDGED PEPTIDE; GUANOSINE TRIPHOSPHATE; MOLECULAR MOTOR; MYOSIN; RAB PROTEIN; RAB27A PROTEIN; UNCLASSIFIED DRUG; DYNEIN ADENOSINE TRIPHOSPHATASE; MYOSIN VIIA; RAB27A PROTEIN, HUMAN; RAB27A PROTEIN, MOUSE;

ARTICLE; CELL NUCLEUS; CELL ORGANELLE; CELL TRANSPORT; COMPLEX FORMATION; CONTROLLED STUDY; CYTOSKELETON; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MELANOSOME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PIGMENT CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEFECT; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RETINA CELL; AMINO ACID SEQUENCE; ANIMAL; ANTIBODY SPECIFICITY; GENE LIBRARY; METABOLISM; MOLECULAR GENETICS; RETINA; SEQUENCE ALIGNMENT; TWO HYBRID SYSTEM; ULTRASTRUCTURE;

AMINO ACID SEQUENCE; ANIMAL; GENE LIBRARY; HUMAN; MELANOSOMES; MICE; MOLECULAR SEQUENCE DATA; MYOSINS; ORGAN SPECIFICITY; RAB GTP-BINDING PROTEINS; RETINA; SEQUENCE ALIGNMENT; SUPPORT, NON-U.S. GOV'T; TWO-HYBRID SYSTEM TECHNIQUES; ANIMALS; DYNEIN ATPASE; HUMANS;

EID: 0035984893     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvf090     Document Type: Article

References (23)

1. Rab27a: A key to melanosome transport in human melanocytes
2. Human Usher IB/mouse shaker-1: The retinal phenotype discrepancy explained by the presence/absence of myosin VIIa in the photoreceptor cells
3. Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B
4. 2+-regulated exocytosis in neuroendocrine cells
5. Rab27a regulates the peripheral distribution of melanosomes in melanocytes
6. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain
7. Unconventional myosin VIIa is a novel A-kinase-anchoring protein
8. Vezatin, a novel transmembrane protein, bridges myosin VIIa to the cadherin-catenins complex
9. Mutant myosin VIIa causes defective melanosome distribution in the RPE of shaker-1 mice
10. Myosin VIIa participates in opsin transport through the photoreceptor cilium
11. The melanosome: Membrane dynamics in black and white
12. Mutations in Mlph, encoding a member of the Rab effector family, cause the melanosome transport defects observed in leaden mice
13. Mutations in RAB27A cause Griscelli syndrome associated with haemophagocytic syndrome
14. Novel myosin heavy chain encoded by murine dilute coat colour locus
15. Structural basis of Rab effector specificity: Crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A
16. Two genes are responsible for Griscelli syndrome at the same 15q21 locus
17. Usher syndrome: From genetics to pathogenesis
18. Shaker-1 mutations reveal roles for myosin VIIa in both development and function of cochlear hair cells
19. Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique. Studies in adrenal chromaffin cells
20. Rim1 and Rabphilin-3 bind Rab3-GTP by composite determinants partially related through N-terminal α-helix motifs
21. A mutation in Rab27a causes the vesicle transport defects observed in ashen mice
22. Rhodopsin transport in the membrane of the connecting cilium of mammalian photoreceptor cells
23. Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle