5′-End RET splicing: Absence of variants in normal tissues and intron retention in pheochromocytomas

Oncology

Volumn 63, Issue 1, 2002, Pages 84-91

  Le Hir, Hervé ^a   Charlet Berguerand, Nicolas ^a   De Franciscis, Vittorio ^b   Thermes, Claude ^a,c  

^a CENTRE DE GÉNÉTIQUE MOLÉCULAIRE   (France)

^b CNR   (Italy)

^c CNRS   (France)

Author keywords

Intron retention; MEN2; Pheochromocytomas; RET; Splicing

Indexed keywords

ENZYME VARIANT; PROTEIN RET; PROTEIN TYROSINE KINASE; DROSOPHILA PROTEIN; ISOPROTEIN; MESSENGER RNA; ONCOPROTEIN; RET ONCOGENE PROTEIN, DROSOPHILA;

ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME ASSAY; GENE CONTROL; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRON; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; RNA SPLICING; SAMPLING; TISSUE LEVEL; TUMOR CELL; 5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; CELL CULTURE; GENETICS; METABOLISM;

5' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; DROSOPHILA PROTEINS; HUMANS; INTRONS; PHEOCHROMOCYTOMA; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0035984663     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000065725     Document Type: Article

References (38)

1. Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy
2. Aberrant splicing but not mutations of TSG101 in human breast cancer
3. Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer
4. Identification of an exon 3 deletion splice variant androgen receptor mRNA in human breast cancer
5. Altered expression of heterogeneous nuclear ribonucleoproteins and SR factors in human colon adenocarcinoma
6. A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: A potential role in derepression of neuroendocrine genes and a useful clinical marker
7. Novel transcripts of fibroblast growth factor receptor 3 reveal aberrant splicing and activation of cryptic splice sequences in colorectal cancer
8. Relative expression of the RET9 and RET51 isoforms in human pheochromocytomas
9. Isolation and sequencing of cDNAs for splice variants of growth hormone-releasing hormone receptors from human cancers
10. Coupling of signal transduction to alternative pre-mRNA splicing by a composite splice regulator
11. Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis
12. Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors
13. Heterogeneous ribonucleoprotein A1 is part of an exon-specific splice-silencing complex controlled by oncogenic signaling pathways
14. Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains
15. Expression of the c-ret proto-oncogene during mouse embryogenesis
16. Developmental expression of the RET protooncogene
17. Presence of physiologically stimulated RET in adult rat brain: Induction of RET expression during nerve regeneration
18. Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues
19. Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
20. RET mutations in human disease
21. The phenotypes associated with ret mutations in the multiple endocrine neoplasia type 2 syndrome
22. Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line
23. The physical map of the human RET proto-oncogene
24. Signal transduction by the receptor tyrosine kinase Ret
25. Characterization of RET proto-oncogene 3′ splicing variants and polyadenylation sites: A novel C-terminus for RET
26. Multiple mRNA isoforms of the human RET proto-oncogene generated by alternate splicing
27. Expression of RET 3′ splicing variants during human kidney development
28. Mechanisms of activation of the ret pro-tooncogene by multiple endocrine neoplasia 2A mutation
29. Distinct biological properties of two RET isoforms activated by MEN 2A and MEN 2B mutations
30. Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain
31. The expression of RET and its multiple splice forms in developing human kidney
32. High levels of tyrosine phosphorylated proto-ret in sporadic pheochromocytomas
33. Structural analysis of the human ret proto-oncogene using exon trapping
34. Unusual retention of introns in CD44 gene transcripts in bladder cancer provides new diagnostic and clinical oncological opportunities
35. Abnormal retention of intron 9 in CD44 gene transcripts in human gastrointestinal tumors
36. Accumulation of immature intron-containing CD44 gene transcripts in breast cancer tissues
37. CD44 expression in cervical intraepithelial neoplasia (CIN) and carcinoma
38. Multiple intron retention occurs in tumor cell CD44 mRNA processing