Increased synaptosomal [3H] GABA uptake in the rat brainstem after facial carrageenan injections

Pain

Volumn 98, Issue 3, 2002, Pages 259-268

  Ng, Chee Hon ^a   Ong, Wei Yi ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Chronic inflammation; Gamma aminobutyric acid transporter; Hyperalgesia; Nociception; Spinal trigeminal nucleus; Trigeminal neuralgia

Indexed keywords

1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID; BETA ALANINE; CARRAGEENAN; NIPECOTIC ACID; SODIUM CHLORIDE; TRITIUM; NEUROTRANSMITTER UPTAKE INHIBITOR;

AMINO ACID ANALYSIS; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN STEM; CONTROLLED STUDY; DISEASE COURSE; FACE; HYPERALGESIA; INFLAMMATION; MALE; NERVE CELL; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SYNAPTOSOME; TRIGEMINAL NUCLEUS; ANIMAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; GROOMING; METABOLISM; PHYSIOLOGY; SUBCUTANEOUS DRUG ADMINISTRATION; WISTAR RAT;

ANIMALS; BRAIN STEM; CARRAGEENAN; FACE; GAMMA-AMINOBUTYRIC ACID; GROOMING; HYPERALGESIA; INJECTIONS, SUBCUTANEOUS; MALE; NEUROTRANSMITTER UPTAKE INHIBITORS; RATS; RATS, WISTAR; SYNAPTOSOMES; TRITIUM;

EID: 0035984440     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(01)00491-2     Document Type: Article

References (69)

1. Orally active and potent inhibitors of gamma-aminobutyric acid uptake
2. Post-embedding immunogold labelling of gamma-aminobutryric acid in lamina II of the spinal trigeminal subnucleus pars caudalis: I. A qualitative study
3. Synaptic interactions between GABAergic-immunoreactive profiles and the terminals of functionally defined myelinated nociceptors in the monkey and cat spinal cord
4. Antagonism of baclofen-induced anti-nociception by intrathecal administration of phaclofen or 2-hydroxy-saclofen, but not deaminovaleric acid in the rat
5. The depressant action of baclofen on the isolated spinal cord of the neonatal rat
6. 3H] gamma-amino butyric acid transport in rat substantia nigra pars reticula synaptosomes: Pharmacological characterization and phorbol ester-induced inhibition
7. GABAergic terminals are presynaptic to primary afferent terminals in the substantia gelatinosa of the rat spinal cord
8. Immunoreactive glutamic acid decarboxylase in the trigeminal nucleus caudalis of the cat: A light and electron-microscopic analysis
9. Competitive inhibition of GABA uptake in rat brain slices by some GABA analogues of restricted conformation
10. GABA transporter heterogeneity: Pharmacology and cellular localization
11. Tiagabine, SK & F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1
12. B receptor site distribution in the rat central nervous system
13. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl] nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier
14. GABA transporter expression in the rat nervous system. Presynaptic mechanisms of neurotransmission
15. Light and microscopic and ultra-structural analysis of GABA-immunoreactive profiles in the monkey spinal cord
16. Increase in GABAergic cells and GABA levels in the spinal cord in unilateral inflammation of the hindlimb in the rat
17. Carrageenan-induced inflammation of the hindlimb provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment
18. B receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy
19. Effects of GABA receptor antagonists on trigeminal subnucleus caudalis nociceptive neurons in normal and neonatally capsaicin-treated adult rats
20. Neuronal, glial and epithelial localization of gamma-aminobutryric acid transporter 2, a high affinity membrane transporter in the cerebral cortex and neighbouring structures
21. Selective depression of synaptic excitation in cat spinal neurones by baclofen: An iontophoretic study
22. B receptors on A-delta and C primary afferents
23. Intrathecal baclofen and muscimol, but not midazolam are anti-nociceptive in the rat-formalin model
24. Spinal and trigeminal mechanisms of nociception
25. Localisation of messenger RNAs encoding three GABA transporters in rat brain: An in situ hybridization study
26. B antagonists in the trigeminal nucleus of the rat
27. Glial transporters for glutamate, glycine, and GABA: II. GABA transporters
28. Cloning and expression of a rat brain GABA transporter
29. Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold
30. Primary afferent interactions: Analysis of calcitonin gene-related peptide-immunoreactive terminals in contact with unlabelled and GABA-immunoreactive profiles in the monkey dorsal horn
31. Production of specific antibodies against GABA transporter subtypes (GAT-1, GAT-2, GAT-3) and their application to immunocytochemistry
32. Uptake and metabolism of gamma-aminobutryric acid by neurons and glial cells
33. B receptor mediated modulation of presynaptic currents and excitatory transmission at fast central synapse
34. Spillover in the spotlight
35. A) receptors in the rat caudal trigeminal spinal nucleus
36. GABA uptake inhibitors as experimental tools and potential drugs in epilepsy research
37. GABA uptake inhibitors: Relevance to anti-epileptic research
38. Inhibitors of gamma-amino butyric acid transport as experimental tools and therapeutic agents
39. Expression of a cloned gamma-aminobutryric acid transporter in mammalian cells
40. Anatomical distribution and ultra-structural organization of the GABAergic system in the rat spinal cord. An immunocytochemical study using anti-GABA antibodies
41. Gamma-aminobutyric acid B, but not gamma-aminobutyric acid A receptor activation: Inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro
42. Anti-nociception produced by microinjection of L-glutamate into the ventromedial medulla of the rat: Mediation by spinal GABAA receptors
43. Direct observations of synapses between GABA-immunoreactive boutons and muscle afferent terminals in lamina VI of the cat's spinal cord
44. GAT-1, a high affinity GABA plasma membrane transporter, is localized to neurons and astroglia in the cerebral cortex
45. GAT-3, a high affinity GABA plasma membrane transporter, is localized to astrocytic processes, and it is not confined to the vicinity of GABAergic synapses in the cerebral cortex
46. Peripheral inflammation is associated with increased glutamic acid decarboxylase immunoreactivity in the rat spinal cord
47. A light and electron microscopic study of the GABA transporter GAT-3 in the monkey basal ganglia and brainstem
48. Increased expression of gamma-aminobutyric acid transporters GAT-1 and GAT-3 in the spinal trigeminal nucleus after facial carrageenan injections
49. Characterisation of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor
50. High affinity GABA receptors autoradiographic localisation
51. Characterization of nociceptors and their activation of neurons in the superficial dorsal horn: First steps for the sensation of pain
52. B receptors present on primary afferent terminals of the spinal cord?
53. B receptor binding sites in mammalian spinal cord
54. Nociceptive responses to altered GABAergic activity at the spinal cord
55. GABA plasma membrane transporters GAT-1 and GAT-3, display different distributions in the rat hippocampus
56. D-Baclofen is an antagonist at baclofen receptors mediating anti-nociception in the spinal cord
57. 3H] gamma-aminobutyric acid in rat hippocampal synaptosomes
58. Acute and chronic craniofacial pain: Brainstem mechanism of nociceptive transmission and neuroplasticity, and their clinical correlates
59. Reduction of 3H-muscimol binding sites in rat dorsal spinal cord after neonatal capsaicin treatment
60. B receptor-mediated responses in the lateral geniculate nucleus
61. The GABA transporter and its inhibitors
62. NNC-711, a novel potent and selective gamma-amino butyric acid uptake inhibitor: Pharmacological characterisation
63. Short external loops as potential substrate binding site of gamma-aminobutryric acid transporters
64. GABA-like immunoreactivity in type I glomeruli of rat substantia gelatinosa
65. GABA-immunoreactive neurons in the dorsal horn of the rat spinal cord
66. B receptor mediated responses in GABAergic projection neurones of the rat nucleus reticularis thalami in vitro
67. Baclofen is anti-nociceptive in the spinal intrathecal space of animals
68. Ethical guidelines for investigation of experimental pain in conscious animals