Retroviral interleukin 1α gene transfer in bone marrow stromal cells in a primate model: Induction of myelopoiesis stimulation

British Journal of Haematology

Volumn 118, Issue 3, 2002, Pages 875-884

  De Revel, Thierry ^a,b   Becard, Nicolas ^a   Sorg, Tania ^c   Rousseau, Sandrine ^a   Spano, Jean Philippe ^a   Thiebot, Hugues ^a   Methali, Magid ^c   Gras, Gabriel ^a   Le Grand, Roger ^a   Dormont, Dominique ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b PERCY MILITARY HOSPITAL   (France)

^c TRANSGENE S A   (France)

Author keywords

Gene transfer; Haemopoiesis; IL 1 ; Primate model; Stromal cells

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1ALPHA; RETROVIRUS VECTOR; INTERLEUKIN 1;

ADOPTIVE IMMUNOTHERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CELL; BONE MARROW CELL; CLONOGENESIS; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE TRANSFER; HUMAN; HUMAN CELL; LEUKOCYTE COUNT; MARKER GENE; MOLONEY LEUKEMIA ONCOVIRUS; MONOCYTE; MYELOPOIESIS; NONHUMAN; POLYMORPHONUCLEAR CELL; PRIMATE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; STAINING; STROMA CELL; SUPERNATANT; TOXICITY; VIRAL GENE THERAPY; ANIMAL; CLONOGENIC ASSAY; CULTURE TECHNIQUE; CYTOLOGY; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MACACA; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; BONE MARROW CELLS; CELL CULTURE TECHNIQUES; COLONY-FORMING UNITS ASSAY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; INTERLEUKIN-1; LEUKOCYTE COUNT; MACACA FASCICULARIS; MOLONEY MURINE LEUKEMIA VIRUS; MYELOPOIESIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STROMAL CELLS; TRANSDUCTION, GENETIC; UP-REGULATION;

EID: 0035982523     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2002.03672.x     Document Type: Article

References (55)

1. LacZ and interleukin-3 expression in vivo after retroviral transduction of marrow-derived human osteogenic mesenchymal progenitors
2. The essential cells of the hemopoietic microenvironment
3. Cotransplantation of human stromal cell progenitors into pre-immune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation
4. Interleukin-1 stimulates granulocyte-macrophage colony-stimulating activity release by vascular endothelial cells
5. RANTES, IFN gamma, CCR1, and CCR5 mRNA expression in peripheral blood, lymph nodes and bronchoalveolar lavage mononuclear cells during primary simian immunodeficiency virus of macaques
6. Bone marrow stromal cells as targets for gene therapy of hemophilia A
7. Long-term persistence of human bone marrow stromal cells transduced with factor VIII-retroviral vectors and transient production of therapeutic levels of human factorVIII in non-myloablated immunodeficient mice
8. A phase I trial of recombinant human interleukin-1β alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer
9. Mesenchymal stem cells are capable of homing to the bone marrow of non-human primates following systemic infusion
10. Biologic basis for interleukin-1 in disease
11. Bone marrow stromal cells as a vehicle for gene transfer
12. Intramarrow cytokine gene transfer by adenoviral vectors in dogs
13. Effects of interleukin-1 on hematopoietic progenitors: Evidence of stimulatory and inhibitory activities in a primate model
14. Physiological mechanisms of stem cell regulation in bone marrow transplantation and haemopoiesis
15. A new technique for the assay of infectivity of human adenovirus 5 DNA
16. Characteristics of a human cell line transformed by DNA from human adenovirus type 5
17. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies
18. Cytokine expression by human marrow-derived mesenchymal progenitors cells in vitro: Effects of dexamethasone and IL-1 alpha
19. Systemic delivery of human growth hormone or human factor IX in dogs by reintroduced genetically modified autologous bone marrow stromal cells
20. Recombinant human interleukin-1 beta analogue as a regulator of hematopoiesis in patients receiving chemotherapy for urogenital cancers
21. Interleukin-1 stimulates fibroblasts to synthesize granulocyte-macrophage and granulocyte colony-stimulating factors
22. Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma
23. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy
24. Stimulation of hemopoiesis in canines by in vivo administration of recombinant human interleukin-1
25. Interleukin-1 regulates hematopoietic activity, a role previously ascribed to hemopoietin 1
26. Protective effects of IL-1 on human hematopoietic progenitor cells treated in vitro with 4-hydroxycyclophosphamide
27. The influence of IL-1 treatment on the reconstitution of the hemopoietic and immune systems after sublethal radiation
28. The interleukin-1 receptor binds the human interkeukin-1 alpha precursor but not the interleukin-1 beta precursor
29. Dicistronic targeting constructs: Reporters and modifiers of mammalian gene expression
30. Phase I study of recombinant interleukin-1β in patients undergoing autologous bone marrow transplantation for acute myelogenous leukemia
31. Cytokines in therapy of radiation injury
32. Interleukin-1 is a radioprotector
33. The in vivo effects of interleukin-1. I: Bone marrow cells are induced to cycle after administration of interleukin-1
34. Synergy of IL-1 and stem cell factor in radioprotection of mice is associated with IL-1 up-regulation of m-RNA and protein expression for c-kit on bone marrow cells
35. Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: Analysis of gene transduction of long-lived progenitors
36. Multilineage potential of adult mesenchymal stem cells
37. Stromal cell regulation of lymphoid and myeloid differentiation
38. Evidence of allogenic stromal engraftment in bone marrow using canine mesenchymal stem cells
39. Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos
40. Production of colony stimulating factor in long-term bone marrow cultures
41. Hemolytic leukemia and erythroleukemia, two distinct pathogenic effects of Friend MuLV: Mapping of the effects to different regions of the viral genome
42. The effects of treatment with interleukin-1α on platelet recovery after high-dose carboplatin
43. The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies
44. Interleukin-1 accelerates murine granulocyte recovery following treatment with cyclophosphamide
45. Preliminary report: Effects of interleukin-1 on platelet counts
46. Interleukin-1 administration before lethal irradiation and allogenic bone marrow transplantation: Early transient increase of peripheral granulocytes and successful engraftment with accelerated leukocyte, erythrocyte, and platelet recovery
47. Cellular interactions
48. A small and efficient dimerization-packaging signal of rat VL30 and its use in murine leukemia virus VL30-derived vectors for gene transfer
49. Cloning and expression of a Puromycin N-acetyl transferase gene from Streptomyces lividans and Escherichia Coli
50. A trial of recombinant human interleukin-1 in parients with severe refractory aplastic anaemia
51. Interleukin-1α administered after autologous transplantation: A phase I/II clinical trial
52. Interleukin-1 regulation of hematopoietic growth factor production by human stromal fibroblasts
53. Interleukin-1 stimulates fibroblasts to produce granulocyte-macrophage colony-stimulating activity and prostaglandin E2
54. Radioprotection of hematopoietic stem cells by interleukin-1