Effects of ageing and arthritic disease on nitric oxide production by human articular chondrocytes

Experimental and Molecular Medicine

Volumn 33, Issue 4, 2001, Pages 299-302

  Min, Byoung Hyun ^a   Kim, Hyeon Joo ^a   Lim, Hanjo ^a   Park, Chang Shin ^b   Park, So Ra ^b  

^a Ajou University   (South Korea)

^b Inha University School of Medicine   (South Korea)

Author keywords

Ageing; Human articular chondrocytes; Interleukin 1; Nitric oxide; Osteoarthritis

Indexed keywords

AMINOGUANIDINE; COLLAGEN; INTERLEUKIN 1BETA; NITRIC OXIDE;

AGING; ARTHRITIS; ARTICLE; CARTILAGE CELL; COLLAGEN SYNTHESIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; DISEASE ACTIVITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; OSTEOARTHRITIS; PHENOTYPE; SPECIES DIFFERENCE;

ANIMALIA;

EID: 0035980920     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2001.48     Document Type: Article

References (8)

1. Amin AR, Di Cesare PE, Vyas P, Attr M, Tzeng E, Billiar TR, Stuchin SA, Abramson SB. The expression and regulation of nitric oxide synthase in human osteoarthritis-affected chondrocytes: Evidence for up-regulated neuronal nitric oxide synthase. J Exp Med 1995;182:2097-102
2. Barnett CH, Cochrane W, Palfrey AJ. Age changes in articular cartilage of rabbits. Ann Rheum Dis 1963;22:389-95
3. Blanco FJ, Geng Y, Lotz M. Differentiation-dependent effects of IL-1 and TGF-β on human articular chondrocyte proliferation are related to inducible nitric oxide synthase expression. J Immunol 1995;154:4018-26
4. Cao M, Weterhausen-Larson A, Niyibizi C, Kavalkovich K, Georgescu HI, Rizzo CF, Hebda PA. Nitric oxide inhibits the synthesis of type II collagen without altering Col2A mRNA abundance: prolyl hydroxylase as a possible target. Biochem J 1997;324:305-10
5. 15N] nitrate in biological fluids. Anal Biochem 1982;126:131-38
6. Hauselmann HJ, Stefanovic-Racic M, Michel BA, Evans CH. Differences in nitric oxide production by superficial and deep human articular chondrocytes: Implications for proteoglycan turnover in inflammatory joint diseases. J Immunol 1998;160: 1444-48
7. Jang D, Murrel GAC. Nitric oxide in arthritis. Free Radical Biol Med 1998;24:1511-19
8. Khatib AM, Siegfreid G, Messai H, Quintero M, Barbara A, Mitrovic RD: Basal and induced nitric oxide and cGMP productions are decreased in senescent rat articular chodnrocytes. Mech Ageing Devol 1998;101:21-32