Transcriptional regulation of vascular development

Circulation Research

Volumn 89, Issue 5, 2001, Pages 380-388

  Oettgen, Peter ^a  

^a HARVARD INSTITUTES OF MEDICINE   (United States)

Author keywords

Angiogenesis; Gene regulation; Transcription; Vasculogenesis

Indexed keywords

PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR;

ANGIOGENESIS; CELL DIFFERENTIATION; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; GENE DISRUPTION; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC ANALYSIS; GENETIC CONSERVATION; HEMATOPOIESIS; HYPOXIA; NONHUMAN; PERICYTE; PRIORITY JOURNAL; REGULATOR GENE; REVIEW; STEM CELL; TRANSCRIPTION REGULATION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

EID: 0035980163     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1701.095958     Document Type: Review

References (69)

1. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system
2. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
3. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
4. Role of Ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter
5. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice
6. Role of SCL/Tal-1, GATA, and Ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development
7. A cAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase (vascular endothelial growth factor receptor 1) gene
8. Role of the Ets transcription factors in the regulation of the vascular- specific Tie2 gene
9. The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis
10. The SCL gene specifies haemangioblast development from early mesoderm
11. Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos
12. Elf-1 is a transcriptional regulator of the Tie2 gene during vascular development
13. Inhibition of angiogenesis on the chicken chorioallantoic membrane by Ets 1 antisense oligodeoxyri-bonucleotides
14. Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development
15. Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia
16. Does oncogene c-ets 1 participate in the regulation of tumor angiogenesis?
17. The mouse GATA-2 gene is expressed in the para-aortic splanchnopleura and aorta-gonads and mesonephros region
18. Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor
19. 2 tension
20. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
21. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
22. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
23. Role of tissue factor in embryonic blood vessel development
24. Defective vascularization of HIF-1α-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
25. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
26. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
27. The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
28. An essential role for p300/CBP in the cellular response to hypoxia
29. Mice homozygous for a truncated form of CREB-binding protein exhibit defects in hematopoiesis and vasculo-angiogenesis
30. Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
31. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
32. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
33. Placental vascularisation requires the AP-1 component fral
34. The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis
35. The bHLH-Zip transcription factor Tfeb is essential for placental vascularization
36. Induction of the angiogenic phenotype by Hox D3
37. Hhex and scl function in parallel to regulate early endothelial and blood differentiation in zebrafish
38. A common precursor for primitive erythropoiesis and definitive haematopoiesis
39. A common precursor for hematopoietic and endothelial cells
40. Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages
41. Vezfl: A Zn finger transcription factor restricted to endothelial cells and their precursors
42. The basic helix-loop-helix transcription factor HESR1 regulates endothelial cell tube formation
43. Gridlock, an HLH gene required for assembly of the aorta in zebrafish
44. Homeobox B3 promotes capillary morphogenesis and angiogenesis
45. Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro and in vivo
46. PDGF, TGF-β, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate
47. Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact
48. Requirement of the MADS-box transcription factor MEF2C for vascular development
49. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
50. The cytoplasmic domain of the ligand ephrinB2 is required for vascular morphogenesis but not cranial neural crest migration
51. The basic helix-loop-helix transcription factor, dHAND, is required for vascular development
52. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL
53. Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1
54. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL
55. Protein dimerization between Lmo2 (Rbtn2) and Tall alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice
56. The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
57. The LIM-domain binding protein Ldb1, and its partner LMO2 act as negative regulators of erythroid differentiation
58. The oncogenic LIM-only transcription factor Lmo2 regulates angiogenesis but not vasculogenesis in mice
59. Biochemical and molecular characterization of the chicken cysteine-rich protein, a developmentally regulated LIM-domain protein that is associated with the actin cytoskeleton
60. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure
61. Embryonic expression suggests an important role for CRP2/SmLIM in the developing cardiovascular system
62. ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis
63. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts
64. Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding
65. A role for hematopoietic stem cells in promoting angiogenesis
66. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development
67. Fas ligand gene transfer to the vessel wall inhibits neointima formation and overrides the adenovirus-mediated T cell response
68. Tissue repair with a therapeutic transcription factor
69. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1α/VP16 hybrid transcription factor