Nicotinic receptors in Lymnaea stagnalis neurons are blocked by α-neurotoxins from cobra venoms

Neuroscience Letters

Volumn 309, Issue 3, 2001, Pages 189-192

  Vulfius, C A ^a   Krasts, I V ^a   Utkin, Yu N ^b   Tsetlin, V I ^b  

^a INSTITUTE OF CELL BIOPHYSICS   (Russian Federation)

^b SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

Neurotoxins; 7, Cl current; Acetylcholine; Lymnaea neurons; Nicotinic receptors; Voltage clamp

Indexed keywords

ACETYLCHOLINE; ALPHA NEUROTOXIN; CHLORINE; CHOLINERGIC RECEPTOR; NEUROTOXIN; NEUROTOXIN II; NICOTINIC RECEPTOR; RECEPTOR SUBUNIT; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL CELL; APLYSIA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; IC 50; INHIBITION KINETICS; ION CURRENT; LYMNAEA; NONHUMAN; PRIORITY JOURNAL; VERTEBRATE; VOLTAGE CLAMP;

ACETYLCHOLINE; ANIMALS; COBRA NEUROTOXINS; COBRA VENOMS; LYMNAEA; NEURONS; NEUROTOXINS; RECEPTORS, NICOTINIC; VASODILATOR AGENTS;

EID: 0035979866     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02081-X     Document Type: Article

References (13)

1. Two-component desensitization of nicotinic receptors induced by acetylcholine agonists in Lymnaea stagnalis neurones
2. α-Conotoxin Imi exhibits subtype-specific nicotinic acetylcholine receptor blockade: Preferential inhibition of homomeric α7 and α9 receptors
3. Ionic mechanisms of a two-component cholinergic inhibition in Aplysia neurones
4. Three acetylcholine receptors in Aplysia neurones
5. Effects of α-toxins from Bungarus multicinctus and Bungarus caeruleus on cholinergic responses in Aplysia neurones
6. Two distinct nicotinic receptors, one pharmacologically similar to the vertebrate α7-containing receptor, mediate Cl currents in Aplysia neurons
7. Ion current of excited cholinergic membrane of the giant isolated snail neurones
8. Intracellular perfusion
9. Chemical engineering of a three-fingered toxin with anti-α7 neuronal acetylcholine receptor activity
10. Only snake curaremimetic toxins with a fifth disulfide bond have high affinity for the neuronal α7 nicotinic receptor
11. "Weak toxin" from Naja kaouthia is a nontoxic antagonist of α7 and muscle-type nicotinic acetylcholine receptors
12. First tryptophan-containing weak neurotoxin from cobra venom
13. The action of cholinomimetics and cholinolytics on the gastropod neurons