Does bilirubin play a role in the pathogenesis of both cholesterol and pigment gallstone formation? Direct and indirect influences of bilirubin on bile lithogenicity

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1534, Issue 2-3, 2001, Pages 78-84

  Nakai, Kuniharu ^a   Tazuma, Susumu ^a   Ochi, Hidenori ^a   Chayama, Kazuaki ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Bile lithogenicity; Cholesterol crystal; Unconjugated bilirubin

Indexed keywords

BILE SALT; BILIRUBIN; CHOLESTEROL; LIPID; PHOSPHATIDYLCHOLINE; TAUROCHOLIC ACID;

ARTICLE; BILE SECRETION; CHOLELITHIASIS; CHOLESTEROL STONE; CONCENTRATION RESPONSE; CRYSTALLIZATION; GALLSTONE FORMATION; MOLECULAR WEIGHT; PATHOGENESIS; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

BILE; BILE PIGMENTS; BILIRUBIN; CHOLELITHIASIS; CHOLESTEROL; CRYSTALLIZATION; HUMANS; MICROSCOPY, VIDEO; SOLUTIONS; SPECTROPHOTOMETRY;

EID: 0035977457     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(01)00173-1     Document Type: Article

References (23)

1. Microstructure of gallstone
2. A layerwise quantitation of human cholesterol gallstone constituents
3. A rapid and quantitative high performance liquid chromatographic method for assaying bilirubin and its conjugates in bile
4. Interactions of unconjugated bilirubin with bile salts
5. Unconjugated bilirubin and cholesterol gallstone formation
6. Molecular and micellar associations in the pH-dependent stable and metastable dissolution of unconjugated bilirubin by bile salts
7. Inhibition of biliary phospholipid and cholesterol secretion by bilirubin in the Sprague-Dawley and Gunn rat
8. Effects of bilirubin ditaurate on biliary secretion of proteins and lipids: Influence on the hepatic vesicle transport system
9. Fatty acid composition of lecithin is a key factor in bile metastability in supersaturated model bile systems
10. Simultaneous microanalysis of biliary cholesterol, bile acids and fatty acids in lecithin using capillary column gas chromatography: An advantage to assess bile lithogenicity
11. Lecithin hydrophobicity modulates the process of cholesterol crystal nucleation and growth in supersaturated model bile systems
12. Partial replacement of bile salts causes marked changes of cholesterol crystallization in supersaturated model bile systems
13. Transport of conjugated bilirubin and other organic anions in bile: Relation to biliary lipid structures
14. Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile
15. Nucleation time: A key factor in the pathogenesis of cholesterol gallstone disease
16. A sensitive method for determination of cholesterol growth using model solutions of supersaturated bile
17. A new method for the rapid measurement of cholesterol crystallization in model biles using a spectrophotometric microplate reader
18. Rapid determination by centrifugal ultrafiltration of inter-mixed micellar/vesicular (non-lecithin-associated) bile salt concentrations in model bile: Influence of Donnan equilibrium effects
19. Quantitative assessment of comparative potencies of cholesterol-crystal-promoting factors: Relation to mechanistic characterization
20. Influence of cholesterol crystallization effector proteins on vesicle fusion in supersaturated model bile
21. Monoconjugated bilirubin as a possible factor in cholesterol gallstone pathogenesis
22. Complete mapping of crystallization pathways during cholesterol precipitation from model bile: Influence of physical-chemical variables of pathophysiologic relevance and identification of a stable liquid crystalline state in cold, dilute and hydrophilic bile salt-containing systems
23. Effects of bile salt hydrophobicity on crystallization of cholesterol in model bile