The anti-inflammatory activities of cannabinoid receptor ligands in mouse peritonitis models

European Journal of Pharmacology

Volumn 432, Issue 1, 2001, Pages 107-119

  Smith, Sidney R ^a   Denhardt, Georgetta ^a   Terminelli, Carol ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cannabinoid receptor agonist; Cannabinoid receptor antagonist; Chemokine; Peritonitis; Staphylococcus enterotoxin A; Thioglycollate

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID 1 RECEPTOR; CHEMOATTRACTANT; CHEMOKINE; DEXANABINOL; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; RIMONABANT; STAPHYLOCOCCUS ENTEROTOXIN A; THIOGLYCOLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DRUG ACTIVITY; DRUG EFFECT; FEMALE; LEUKOCYTE MIGRATION INHIBITION; MONOCYTE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONEAL CAVITY; PERITONITIS; PRIORITY JOURNAL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASCITIC FLUID; CELL MOVEMENT; CHEMOKINE CCL2; CHEMOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENTEROTOXINS; FEMALE; GENOTYPE; LIGANDS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; MONOKINES; MORPHOLINES; NAPHTHALENES; NEUTROPHILS; PERITONITIS; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SPECIFIC PATHOGEN-FREE ORGANISMS; TETRAHYDROCANNABINOL; THIOGLYCOLATES;

EID: 0035976821     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01477-7     Document Type: Article

References (24)

1. Pleural mesothelial cell expression of C-C (monocyte chemotactic peptide) and C-X-C (interleukin-8) chemokines
2. Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model
3. Role of resident peritoneal macrophages and mast cells in chemokine production and neutrophil migration in acute inflammation: Evidence for an inhibitory loop involving endogenous IL-10
4. Effects of cannabinoid receptor ligands on LPS-induced pulmonary inflammation in mice
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6. Neutrophil migration induced by staphylococcal enterotoxin type A in mice: A pharmacological analysis
7. Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
8. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse
9. HU-308: A specific agonist for CB2, a peripheral cannabinoid receptor
10. The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder
11. Opioid receptors on bone marrow neutrophils modulate chemotaxis and CD11b/CD18 expression
12. N-(2-hydoxyethyl) hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation
13. Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors
14. SR1442528, the first potent and selective antagonist of the CB2 cannabinoid receptor
15. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE
16. In vivo and in vitro treatment with the synthetic cannabinoid CP55,940 decreases the in vitro migration of macrophages in the rat: Involvement of both CB1 and CB2 receptors
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23. In vivo effect of Staphyloccal enterotoxin A on peripheral blood lymphocytes
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