Synthesis and biological activity of D- and L-chiro-Inositol 2,3,4,5-tetrakisphosphate: Design of a novel and potent inhibitor of Ins(3,4,5,6)P4 1-kinase/Ins(1,3,4)P3 5/6-kinase

Journal of Medicinal Chemistry

Volumn 44, Issue 18, 2001, Pages 2984-2989

  Liu, C ^a   Riley, A M ^a   Yang, X ^b   Shears, S B ^b   Potter, B V L ^a  

^a University of Bath   (United Kingdom)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INOSITOL 1,3,4 TRISPHOSPHATE 5 KINASE INHIBITOR; INOSITOL 1,3,4 TRISPHOSPHATE 6 KINASE INHIBITOR; INOSITOL 2,3,4,5 TETRAKISPHOSPHATE; INOSITOL 3,4,5,6 TETRAKISPHOSPHATE KINASE INHIBITOR; INOSITOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME ANALYSIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; AORTA; CATTLE; ENZYME INHIBITORS; INOSITOL PHOSPHATES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035974652     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000553k     Document Type: Article

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