Up-Regulation of ninjurin Expression in Human Hepatocellular Carcinoma Associated with Cirrhosis and Chronic Viral Hepatitis

Molecules and Cells

Volumn 11, Issue 2, 2001, Pages 151-157

  Kim, Jae Wha ^a   Moon, Ae Ran ^a   Kim, Joo Heon ^b   Yoon, Sun Young ^a   Oh, Goo Taeg ^a   Choe, Yong Kyung ^a   Choe, In Seong ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Eulji University   (South Korea)

Author keywords

Chronic Hepatitis; Cirrhotic Liver Tissues; Hepatocellular Carcinoma; Liver Regeneration; Up Regulation of ninjurin Expression

Indexed keywords

NERVE CELL ADHESION MOLECULE; NERVE GROWTH FACTOR; NINJ1 PROTEIN, HUMAN; RECOMBINANT PROTEIN; RNA;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHRONIC HEPATITIS; GENETICS; HISTOLOGY; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER TUMOR; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; UPREGULATION; VIRUS HEPATITIS;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL ADHESION MOLECULES, NEURONAL; HEPATITIS, CHRONIC; HEPATITIS, VIRAL, HUMAN; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CIRRHOSIS; LIVER NEOPLASMS; NERVE GROWTH FACTORS; RECOMBINANT PROTEINS; RNA; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 0035972245     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Araki, T. and Milbrandt, J. (1996) Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. Neuron 17, 353-361.
2. Araki, T., Zimonjic, D. B., Popescu, N. C., and Milbrandt, J. (1997) Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. J. Biol. Chem. 272, 21373-21380.
3. Beasley, R. P., Hwang, L. Y., Lin, C. C., and Chien, C. S. (1981) Hepatocellular carcinoma and hepatitis B virus. Lancet 11, 1129-1133.
4. Bernstein, L. R. and Liotta, L. A. (1994) Molecular mediators of interactions with extracellular matrix components in metastasis and angiogenesis. Curr. Opin. Oncol. 6, 106-113.
5. Bruix, J., Barrera, J. M., Calvet, X., Ercilla, G., Costa, J., Sanchez-Taplas, J. M., Ventura, M., Vail, M., Bruguera, M., Bru, C., et al. (1989) Prevalence of antibodies to hepatitis C virus Spanish patients with hepatocellular carcinoma and chronic hepatitis. Lancet 2, 1004-1006.
6. Chadwick, B. P., Heath, S. K., Williamson, J., Obermayr, F., Patel, L., Sheer, D., and Frischauf, A. (1998) The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSN I). Genomics 47, 58-63.
7. Chung, K. M., Song, O. K., and Jang, S. K. (1997) Hepatitis C virus nonstructural protein 5A contains potential transcriptional activator domains. Mol. Cells 7, 661-667.
8. Edelman, G. M. (1986) Cell adhesion molecules in the regulation of animal form and tissue pattern. Annu. Rev. Cell Biol. 2, 81-116.
9. Gibson, J. B. and Sobin, L. H. (1978) Histological typing of tumors of the liver, biliary tract and pancreas. International histological classification of tumors no. 20. Geneva: WHO, 12-30.
10. Goudie, D., Yuille, M., Leversha, M., Furlong, R., Carter, N., Lush, M., Affara, N., and Ferguson-Smith, M. (1993) Multiple self-healing squamous epitheliomata (ESS1) mapped to chromosome 9q22-q31 in families with common ancestry. Natl. Genet. 3, 165-169.
11. Hadengue, A., NDri, N., and Benhamou, J. P. (1990) Relative risk of hepatocellular carcinoma in HbsAg positive vs alcoholic cirrhosis. A cross-sectional study. Liver 10, 147-151.
12. Harris, C. C. (1990) Hepatocellular carcinogenesis: recent advances and speculations. Cancer Cells 2, 146-148.
13. Ishak, K., Baptista, A., Bianchi, L., Callea, F., De Groote, J., Gudat, F., Denk, H., Desmet, V., Korb, G., and MacSween, R. N. (1995) Histological grading and staging of chronic hepatitis. J. Hepatol. 22, 696-699.
14. +-ATPase γ-subunit. Biochem. Biophys. Acta 1350, 133-135.
15. Kim, J. W., Lee, I. A., Lee, Y., Song, J. C., Choe, Y. K., Hahn, Y. S., Chung, J. H., Chung, T. W., and Choe, I. S. (1998) Increment of efficiency in the identification of noble genes by colony hybridization assay. (Screening of low redundant clones from human fetal cDNA library). Biochem. Mol. Biol. Int. 44, 225-233.
16. Mahoney, P. A., Weber, U., Onofrechuk, P., Biessmann, H., Bryant, P. J., and Goodman, C. S. (1991) The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell 67, 853-868.
17. Matsuzaki, F., Mege, R., Jaffe, S. H., Friedlander, D. R., Gallin, W. J., Goldberg, J. I., Cunningham, B. A., and Edelman, G. M. (1990) cDNAs of cell adhesion molecules of different specificity induce changes in cell shape and border formation in cultured S180 cells. J. Cell Biol 110, 1239-1252.
18. Miyamoto, S., Teramoto, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K., and Yamada, K. M. (1995) Integrin function molecular hierachies of cytoskeletal and signalling molecules. J. Cell Biol. 131, 791-805.
19. Nalpas, B., Driss, F., Pol, S., Hamelin, B., Housset, C., Brechot, C., and Berthelot, P. (1991) Association between HCV and HBV infection in hepatocellular carcinoma and alcoholic liver disease. J. Hepatol. 12, 70-74.
20. Nam, K. S., Kim, J. W., Choi, M. J., Han, M. Y., Choe, I. S., and Chung, T. W. (1993) Production and characterization of monoclonal antibody that simultaneously recognizes methamphetamine and its major metabolites. Biol. Pharm. Bull. 16, 490-492.
21. Saito, I., Miyamura, T., Ohbayashi, A., Harada, H., Katayama, T., Kikuti, S., Watanabe, Y., Koi, S., Onji, M., Ohta, Y., Choo, Q. L., Houghton, M., and Kuo, G. (1990) Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc. Natl. Acad. USA 87, 6547-6549.
22. Sakamoto, M., Hirohashi, S., Tsuda, H., Ino, Y., Shimosato, Y., Yamasaki, S., Makuuchi, M., Hasegawa, H., Terada, M., and Hosoda, Y. (1988) Increasing incidence of hepatocellualr carcinoma possibly associated with non-A non-B hepatitis in Japan, disclosed by hepatitis B virus DNA analysis of surgically resected cases. Cancer Res. 48, 7294-7297.
23. Shibata, M., Morizane, T., Uchida, T., Yamagami, T., Onozuka, Y., Nakano, M., Mitamura, K., and Ueno, Y. (1998) Irregular regeneration of hepatocytes and risk of hepatocellular cacinoma in chronic hepatitis and cirrhosis with hepatitis-C-virus infection. Lancet 351, 1773-1777.
24. Shimoyama, Y., Hirohashi, S., Hirano, S., Noguchi, M., Shimosato, Y., Takeichi, M., and Abe, O. (1989) Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res. 49, 2128-2133.
25. Simonetti, R. G., Camma, C., Florello, F., Cottone, M., Rapicetta, M., Marino, L., Fioentino, G., Craxi, A., Ciccaglione, A., and Gluseppetti, R. (1992) Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis. A case-control study. Ann. Intern. Med. 116, 97-102.
26. Takeichi, M. (1990) Cadherins: a molecular family important in selective cell-cell adhesion. Annu. Rev. Cell Biol. 59, 237-252.
27. Thomas, P. K. (1993) Hereditary sensory neuropathies. Brain Pathol. 3, 57-163.
28. Uchida, T., Koronberg, I., and Peters R. L. (1984) Acute viral hepatitis: morphological and functional correlations in human livers. Hum. Pathol. 15, 2267-2277.