Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells

Neuroscience Letters

Volumn 301, Issue 2, 2001, Pages 99-102

  McGinnis, Kim M ^a   Wang, Kevin K W ^a,b   Gnegy, Margaret E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b PFIZER INC   (United States)

Author keywords

Apoptosis; Ca2+ CaM dependent protein kinase; Caspase 3; k252a; KN93; SH SY5Y cells; Thapsigargin

Indexed keywords

CASPASE 3; K 252A; LACTATE DEHYDROGENASE; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN KINASE (CALCIUM,CALMODULIN); THAPSIGARGIN;

ARTICLE; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUTEINIZING HORMONE RELEASE; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

APOPTOSIS; ASPARTIC ACID; BENZYLAMINES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARBAZOLES; CASPASE 3; CASPASES; CELL SURVIVAL; ENZYME INHIBITORS; HUMANS; NEUROBLASTOMA; NEURONS; PROTEASE INHIBITORS; SULFONAMIDES; THAPSIGARGIN; TUMOR CELLS, CULTURED;

EID: 0035970904     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)01629-9     Document Type: Article

References (17)

1. 2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation
2. Phosphorylation of CREB by CaM-kinase IV activated by CaM-kinase IV kinase
3. 2+/calmodulin-dependent protein kinase II by K252a and its derivative KT5926
4. Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives
5. Cellular events involved in the sensitization of etoposide-resistant cells by inhibitors of calcium-calmodulin-dependent processes. Role for effects on apoptosis, DNA cleavable complex, and phosphorylation
6. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay
7. Staurosporine-induced neuronal apoptosis
8. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
9. Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis
10. Thapsigargin induces apoptosis in SH-SY5Y neuroblastoma cells
11. Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis
12. Characterization of CPP32-like protease activity following apoptotic challenge in SH-SY5Y neuroblastoma cells
13. Calcium/calmodulin-dependent protein kinase type IV (CaMKIV) inhibits apoptosis induced by potassium deprivation in cerebellar granule neurons
14. 2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells
15. 2+/calmodulin-dependent protein kinases type I, II, and IV
16. 2+/CaM kinase)
17. Calmodulin-dependent protein kinase II mediates signal transduction in apoptosis