Haloperidol downregulates phospholipase A2 signaling in rat basal ganglia circuits

Brain Research

Volumn 896, Issue 1-2, 2001, Pages 96-101

  Myers, Carol S ^a,c   Contreras, Miguel A ^a   Chang, Michael C J ^a   Rapoport, Stanley I ^a   Appel, Nathan M ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

Arachidonic acid; Autoradiography; Dopamine; Haloperidol; Phospholipase; Schizophrenia

Indexed keywords

ARACHIDONIC ACID; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DRUG VEHICLE; HALOPERIDOL; PHOSPHOLIPASE A2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTICLE; AUTORADIOGRAPHY; BASAL GANGLION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; FRONTAL CORTEX; LIMBIC SYSTEM; MALE; NIGRONEOSTRIATAL SYSTEM; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STEREOSPECIFICITY;

ANIMALS; ANTIPSYCHOTIC AGENTS; ARACHIDONIC ACID; AUTORADIOGRAPHY; BASAL GANGLIA; BRAIN CHEMISTRY; DOPAMINE; HALOPERIDOL; MALE; PHOSPHOLIPASES A; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; SCHIZOPHRENIA; SIGNAL TRANSDUCTION; TRITIUM;

EID: 0035970786     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02014-5     Document Type: Article

References (44)

1. Brain dopamine receptors: A primer on their current status, basic and clinical
2. Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain
3. In vivo assessment of dopamine uptake in rat medial prefrontal cortex: Comparison with dorsal striatum and nucleus accumbens
4. 11C]arachidonate in normocapnic and hypercapnic monkeys, measured with positron emission tomography
5. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs
6. Arecoline-stimulated brain incorporation of intravenously administered fatty acids in unanesthetized rats
7. 2 activity in schizophrenia
8. 3H]arachidonic acid incorporation in rats with unilateral 6-hydroxydopamine lesions
9. Fatty acid incorporation depicts brain activity in a rat model of Parkinson's disease
10. 2 receptors: Homogenate binding and autoradiographic studies
11. Selective increases in phosphoinositide signaling activity and G protein levels in postmortem brain from subjects with schizophrenia or alcohol dependence
12. The dopamine hypothesis of schizophrenia: Limbic interactions with serotonin and norepinephrine
13. Longitudinal data analysis using generalized linear models
14. 2 receptors in the striatum and frontal cortex following chronic administration of haloperidol
15. Dopamine high-affinity transport site topography in rat brain: Major differences between dorsal and ventral striatum
16. 2 signaling
17. 14C]arachidonate in awake rats, with or without cholinergic stimulation, following unilateral lesioning of nucleus basalis magnocellularis
18. 2 activity in schizophrenics and other psychiatric patients
19. Chronic treatment with clozapine or haloperidol differentially regulates dopamine and serotonin receptors in rat brain
20. Alterations in brain high-energy phosphate and membrane phospholipid metabolism in first-episode, drug-naive schizophrenics
21. Prospects for pharmacotherapy of schizophrenia
22. 2 receptor synergism
23. Differences in the time course of dopaminergic supersensitivity following chronic administration of haloperidol, molindone, or sulpiride
24. In vivo labeling of brain phospholipids by long-chain fatty acids: Relation to turnover and function
25. Developments in the drug treatment of schizophrenia
26. A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: Review and critical analysis
27. Increased phospholipid breakdown in schizophrenia
28. 2 activities in brain of patients with schizophrenia
29. Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat
30. 2 dopamine receptors: Involvement of G proteins in the development of receptor supersensitivity
31. Dopamine axon varicosities in the prelimbic division of the rat prefrontal cortex exhibit sparse immunoreactivity for the dopamine transporter
32. Effects of ritanserin on haloperidol-induced dopamine (D-2) receptor up-regulation in the rat
33. Naloxone-inaccessible σ receptor in rat central nervous system
34. 2 receptor antagonist: Receptor-binding, electrophysiological and neuropharmacological profiles
35. Differential regulation of dopamine receptors after chronic typical and atypical antipsychotic drug treatment
36. 2 activity in the brain of rats
37. 2
38. In vivo cerebral incorporation of radiolabeled fatty acids after acute unilateral orbital enucleation in adult hooded Long-Evans rats
39. Comparison of the distribution of D-1 and D-2 dopamine receptors in the rat brain
40. Localized phosphorus 31 magnetic resonance spectroscopy in chronic schizophrenic patients and normal controls
41. 2) receptors in the rat brain