Cat8 and Sip4 mediate regulated transcriptional activation of the yeast malate dehydrogenase gene MDH2 by three carbon source-responsive promoter elements

Yeast

Volumn 18, Issue 2, 2001, Pages 151-162

  Roth, Stephanie ^a   Schüller, Hans Joachim ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Gluconeogenesis; Glucose repression; Malate dehydrogenase; Saccharomyces cerevisiae; Transcriptional regulation

Indexed keywords

CARBON; DNA BINDING PROTEIN; GENE PRODUCT; GLUCOSE; ISOENZYME; MALATE DEHYDROGENASE; PROTEIN CAT8; PROTEIN HAP4; PROTEIN MDH1; PROTEIN MDH2; PROTEIN MDH3; PROTEIN SIP4; UNCLASSIFIED DRUG; ZINC;

ARTICLE; FUNGAL GENETICS; GLUCONEOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE; TRANSCRIPTION REGULATION; YEAST;

AMINO ACID SEQUENCE; BASE SEQUENCE; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BINDING SITES; CARBON; DNA, FUNGAL; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; ISOENZYMES; MALATE DEHYDROGENASE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

EID: 0035970117     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0061(20010130)18:2<151::AID-YEA662>3.0.CO;2-Q     Document Type: Article

References (49)

1. Isoenzymes of malate dehydrogenase in Saccharomyces cerevisiae
2. Cat8p, the activator of gluconeogenic genes in Saccharomyces cerevisiae, regulates carbon source-dependent expression of NADP-dependent cytosolic isocitrate dehydrogenase (Idp2p) and lactate permease (Jen 1 p)
3. The succinate/fumarate transporter Acr1p of Saccharomyces cerevisiae is part of the gluconeogenic pathway and its expression is regulated by Cat8p
4. Positive regulation of the LPD1 gene of Saccharomyces cerevisiae by the HAP2/HAP3/HAP4 activation system
5. Sequence analysis of a 13.4 kbp fragment from the left arm of chromosome XV reveals a malate dehydrogenase gene, a putative Ser/Thr protein kinase, the ribosomal L25 gene and four new open reading frames
6. Constitutive and carbon source-responsive promoter elements are involved in the regulated expression of the Saccharomyces cerevisiae malate synthase gene MLS1
7. A yeast gene that is essential for release from glucose repression encodes a protein kinase
8. Functional analysis of upstream activating elements in the promoter of the FBP1 gene from Saccharomyces cerevisiae
9. A comprehensive set of sequence analysis programs for the VAX
10. Glucose repression (carbon catabolite repression) in yeast
11. Identification and characterization of HAP4: A third component of the CCAAT-bound HAP2/HAP3 heteromer
12. Yeast carbon catabolite repression
13. CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae
14. Yeast/E. coli shuttle vectors with multiple unique restriction sites
15. Catabolite inactivation in yeast
16. A complex containing two transcription factors regulates peroxisome proliferation and the coordinate induction of beta-oxidation enzymes in Saccharomyces cerevisiae
17. Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae
18. Purification procedure and N-terminal amino acid sequence of yeast malate dehydrogenase isoenzymes
19. Transcriptional control of the yeast acetyl-CoA synthetase gene, ACS1, by the positive regulators CAT8 and ADR1 and the pleiotropic repressor UME6
20. A general method for rapid site-directed mutagenesis using the polymerase chain reaction
21. Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: A new role for SNF1 in the glucose response
22. Importance of a flanking AT-rich region in target site recognition by the GC box-binding zinc finger protein MIG1
23. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE)
24. Molecular genetics of yeast TCA cycle isozymes
25. Isolation and expression of the gene encoding yeast mitochondrial malate dehydrogenase
26. Cloning of yeast HAP5: A novel subunit of a heterotrimeric complex required for CCAAT binding
27. Isolation, nucleotide sequence analysis, and disruption of the MDH2 gene from Saccharomyces cerevisiae: Evidence for three isozymes of yeast malate dehydrogenase
28. Glucose-induced degradation of the MDH2 isozyme of malate dehydrogenase in yeast
29. Glucose-induced phosphorylation of the MDH2 isozyme of malate dehydrogenase in Saccharomyces cerevisiae
30. Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions
31. Evidence for catabolite degradation in the glucose-dependent inactivation of yeast cytoplasmic malate dehydrogenase
32. Yeast HAP2 and HAP3 activators both bind to the CYC1 upstream activation site, UAS2, in an interdependent manner
33. Identification and characterization of regulatory elements in the phosphoenol-pyruvate carboxykinase gene PCK1 of Saccharomyces cerevisiae
34. Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8
35. Deregulation of gluconeogenic structural genes by variants of the transcriptional activator Cat8p of the yeast Saccharomyces cerevisiae
36. Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p
37. The HAP2,3,4 transcriptional activator is required for derepression of the yeast citrate synthase gene, CIT1
38. Pip2p: A transcriptional regulator of peroxisome proliferation in the yeast Saccharomyces cerevisiae
39. A heterodimer of the Zn2Cys6 transcription factors Pip2p and Oaf1p controls induction of genes encoding peroxisomal proteins in Saccharomyces cerevisiae
40. A carbon source-responsive promoter element necessary for activation of the isocitrate lyase gene ICL1 is common to genes of the gluconeogenic pathway in the yeast Saccharomyces cerevisiae
41. Isolation and expression analysis of two yeast regulatory genes involved in the derepression of glucose-repressible enzymes
42. Parameters affecting lithium acetate-mediated transformation of Saccharomyces cerevisiae and development of a rapid and simplified procedure
43. Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase
44. Selection of genes repressed by cAMP that are induced by nutritional limitation in Saccharomyces cerevisiae
45. Transient mRNA responses in chemostat cultures as a method of defining putative regulatory elements: Application to genes involved in Saccharomyces cerevisiae acetyl-coenzyme A metabolism
46. The membrane of peroxisomes in Saccharomyces cerevisiae is impermeable to NAD(H) and acetyl-CoA under in vivo conditions
47. Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes
48. Analysis of positive elements sensitive to glucose in the promoter of the FBP1 gene from yeast