Chemical mechanism and substrate binding sites of NADP-dependent aldehyde dehydrogenase from Streptococcus mutans

Chemico-Biological Interactions

Volumn 130-132, Issue , 2001, Pages 15-28

  Marchal, Stéphane ^a   Cobessi, David ^b   Rahuel Clermont, Sophie ^a   Tête Favier, Frédérique ^b   Aubry, André ^b   Branlant, Guy ^a  

^a Biopôle de l Université de Lorraine   (France)

^b Nancy University CNRS   (France)

Author keywords

Aldehyde dehydrogenase; Chemical mechanism; Nucleophiles; Oxyanion; Substrate binding

Indexed keywords

ALDEHYDE DEHYDROGENASE; BACTERIAL ENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

BINDING SITE; CATALYSIS; CONFERENCE PAPER; DEACYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; NONHUMAN; SITE DIRECTED MUTAGENESIS; STREPTOCOCCUS MUTANS; X RAY CRYSTALLOGRAPHY;

ACYLATION; ALDEHYDE OXIDOREDUCTASES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ENZYME ACTIVATION; GLUTAMIC ACID; GLYCERALDEHYDE 3-PHOSPHATE; HYDROLYSIS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; STREPTOCOCCUS MUTANS; SUBSTRATE SPECIFICITY;

STREPTOCOCCUS MUTANS;

EID: 0035969894     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00218-0     Document Type: Conference Paper

References (12)

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3. Apo and holo crystal structures of a NADP-dependent aldehyde dehydrogenase from Streptococcus mutans
4. Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans
5. The role of Glu268 in the catalytic mechanism of non-phosphorylating glyceraldehyde dehydrogenase from Streptococcus mutans
6. Structure of mitochondrial aldehyde dehydrogenase: The genetic component of ethanol aversion
7. Nucleophilic displacement reactions at the thiolester bond. II. Hydrazinolysis and morpholinolysis in aqueous solutions
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9. Structure of betaine aldehyde dehydrogenase at 2.1 Å resolution
10. Sheep liver cytosolic aldehyde dehydrogenase: The structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases
11. Involvement of glutamate 268 in the active site of human liver mitochondrial (class 2) aldehyde dehydrogenase as probed by site-directed mutagenesis
12. Differences in the roles of conserved glutamic acid residues in the active site of human class 3 and class 2 aldehyde dehydrogenase