Ternary complexes of liver alcohol dehydrogenase

Chemico-Biological Interactions

Volumn 130-132, Issue , 2001, Pages 371-381

  Pocker, Y ^a   Page, Joe D ^a   Li, Hong ^a   Bhat, Clarita C ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Binary complexes; Liver alcohol dehydrogenase; Retinal; Retinoic acid; Retinol; Ternary complexes

Indexed keywords

ADENINE; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE; CARBON; ISOTOPE; LIVER ENZYME; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RETINAL; RETINOIC ACID; RETINOL;

ANIMAL TISSUE; CATALYSIS; COMPLEX FORMATION; CONFERENCE PAPER; ENERGY TRANSFER; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; HORSE; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; NONHUMAN; PROTON TRANSPORT; TEMPERATURE; VITAMIN METABOLISM; X RAY CRYSTALLOGRAPHY;

ALCOHOL DEHYDROGENASE; ANIMALS; HORSES; KINETICS; LIVER; MODELS, MOLECULAR; NAD; OXIDATION-REDUCTION; PROTEIN CONFORMATION; RETINALDEHYDE; SPECTROMETRY, FLUORESCENCE; VITAMIN A;

EQUUS CABALLUS;

EID: 0035969874     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00262-3     Document Type: Conference Paper

References (46)

1. Alcohol dehydrogenase
2. The role of zinc in alcohol dehydrogenases
3. Anion-binding to liver alcohol dehydrogenase, studied by rate of alkylation
4. Enzymatic catalysis in the affinity labelling of liver alcohol dehydrogenase with haloacids
5. The metal environment of alcohol dehydrogenase: Aspects of chemical speciation and catalytic efficiency in a biological catalyst
6. Binding of substrate in a complex of horse liver alcohol dehydrogenase
7. Probes of mechanism and transition state structure in the alcohol dehydrogenase reaction
8. Liver alcohol dehydrogenase
9. Alcohol dehydrogenase: Structure, catalysis and site directed mutagenesis
10. Hydrogen tunneling in enzyme reactions
11. Exponential relationships among multiple hydrogen isotope effects as probes of hydrogen tunneling
12. A link between protein structure and enzyme catalyzed tunneling
13. Unmasking of hydrogen tunneling in the horse liver alcohol dehydrogenase reaction by site directed mutagenesis
14. Hydrogen tunneling in biology
15. Probes of a role for remote binding interactions on hydrogen tunneling in the horse liver alcohol dehydrogenase reaction
16. Liver alcohol dehydrogenase: Kinetic and mechanistic studies
17. Liver alcohol dehydrogenase: Metabolic and energetic aspects
18. The catalytic specificity of liver alcohol dehydrogenase: Vitamin A alcohol and vitamin A aldehyde activities
19. Fluorescence studies of ternary complexes of liver alcohol dehydrogenase
20. Site-specific substituted cobalt(II) horse liver alcohol dehydrogenases
21. Active-site cobalt(II)-substituted horse liver alcohol dehydrogenase: Characterization of intermediates in oxidation and reduction processes as a function of pH
22. A fluorescent analog of nicotinamide adenine dinucleotide
23. 4-ethenocytosine dinucleotide, and analog of nicotinamide adenine dinucleotide. Synthesis and enzyme studies
24. Mechanistic enzymology of liver alcohol dehydrogenase. Kinetic and stereochemical characterization of retinal oxidation and reduction
25. Liver alcohol dehydrogenase-DPN-pyrazole complex: A model of the ternary intermediate in the enzyme reaction
26. The inhibitory effect of ethanol on retinol oxidation by human liver and cattle retina
27. Kinetics of inactivation of erythrocyte carbonic anhydrase by sodium 2,6-pyridinedicarboxylate
28. Differential modification of specificity in carbonic anhydrase catalysis
29. Origin of viscosity effects in carbonic anhydrase catalysis. Kinetic studies with bulky buffers at limiting concentrations
30. Crystallographic investigations of nicotinamide adenine dinucleotide binding to horse liver dehydrogenase
31. Synthetic retinoic acid analogs: Handling and characterization
32. + bound to dehydrogenases
33. Studies on liver alcohol dehydrogenase. I. Equilibria and initial reaction velocities
34. The change in reduced diphosphopyridine nucleolide (DPNH) fluorescence upon combination with liver alcohol dehydrogenase (ADH)
35. On the effects of some heterocyclic compounds on the enzymatic activity of liver alcohol dehydrogenase
36. The role of zinc-bound water in liver alcohol dehydrogenase catalysis
37. Synergism between coenzyme and carboxylate binding in liver alcohol dehydrogenase
38. Effect of pH on pyrazole binding to liver alcohol dehydrogenase
39. Investigation of the nature of enzyme-coenzyme interactions in binary and ternary complexes of liver alcohol dehydrogenase with coenzymes, coenzyme analogues and substrate analogues by ultraviolet absorption and phosphorescence spectroscopy
40. Product inhibition studies on yeast and liver alcohol dehydrogenses
41. Kinetic and mechanistic studies of oxidation of vitamin A alcohol to vitamin A aldehyde by liver alcohol dehydrogenase. The inhibition of ethanol and pyrazole
42. Liver alcohol dehydrogenase: Kinetic and mechanistic studies
43. Kinetics and mechanism of methanol and formaldehyde interconversion and formaldehyde oxidation catalyzed by liver alcohol dehydrogenase
44. The equilibrium between vitamin A alcohol and aldehyde in the presence of alcohol dehydrogenase
45. +
46. Alcohol dehydrogenases