On the role of conserved histidine 106 in 10-formyltetrahydrofolate dehydrogenase catalysis: Connection between hydrolase and dehydrogenase mechanisms

Journal of Biological Chemistry

Volumn 276, Issue 26, 2001, Pages 24030-24037

  Krupenko, Sergey A ^a   Vlasov, Alexander P ^a   Wagner, Conrad ^b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; CATALYSIS; ENZYMES; MUTAGENESIS;

CATALYTIC CENTER;

BIOCHEMISTRY;

ALANINE; ALDEHYDE DEHYDROGENASE; AMINO ACID; ARGININE; ASPARAGINE; ASPARTIC ACID; CYSTEINE; FORMATE TETRAHYDROFOLATE LIGASE; FORMYLTETRAHYDROFOLATE DEHYDROGENASE; GLUTAMIC ACID; GLUTAMINE; HISTIDINE; HYDROLASE; MUTANT PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE INDEPENDENT HYDROLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG; 10 FORMYL 5,8 DIDEAZAFOLATE; 10-FORMYL-5,8-DIDEAZAFOLATE; DRUG DERIVATIVE; FOLIC ACID; N [4 [[(2 AMINO 4 HYDROXY 6 QUINAZOLINYL)METHYL]AMINO]BENZOYL]GLUTAMIC ACID; OXIDOREDUCTASE; QUINAZOLINE DERIVATIVE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CATALYSIS; CELL INCLUSION; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; REACTION ANALYSIS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STATISTICAL SIGNIFICANCE; STRUCTURE ANALYSIS; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HYDROGEN BOND; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALIA; ESCHERICHIA COLI; NEGIBACTERIA;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYSIS; CONSERVED SEQUENCE; FOLIC ACID; HISTIDINE; HYDROGEN BONDING; HYDROLASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035968161     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M009257200     Document Type: Article

References (75)

1. Cook, R. J., Lloyd, R. S., and Wagner, C. (1991) J. Biol. Chem. 266, 4965-4973
2. Kutzbach, C., and Stokstad, E. L. R. (1971) Methods Enzymol. 18, 793-798
3. Rios-Orlandi, E. M., Zarkadas, C. G., and MacKenzie, R. E. (1986) Biochim. Biophys. Acta 87, 24-35
4. Scrutton, M. C., and Beis, I. (1979) Biochem. J. 177, 833-846
5. Schirch, D., Villar, E., Maras, B., Barra, D., and Schirch, V. (1994) J. Biol. Chem. 269, 24728-24735
6. Krupenko, S. A., Wagner, C., and Cook, R. J. (1995) J. Biol. Chem. 270, 519-522
7. Krupenko, S. A., Wagner, C., and Cook, R. J. (1997) J. Biol. Chem. 272, 10266-10272
8. Krupenko, S. A., Wagner, C., and Cook, R. J. (1997) J. Biol. Chem. 272, 10273-10278
9. Hempel, J., Nicholas, H., and Lindahl, R. (1993) Protein Sci. 2, 1890-1900
10. Wagner, C. (1995) in Folate in Health and Disease (Bailey, L., ed) pp. 23-42, Marcel Dekker, Inc., New York
11. Benkovic, S. J. (1984) Trends Biochem. Sci. 9, 320-322
12. Daubner, S. C., Schrimsher, J. L., Schendel, F. J., Young, M., Henikoff, S., Patterson, D., Stubbe, J. A., and Benkovic, S. J. (1985) Biochemistry 24, 7059-7062
13. Mueller, W. T., and Benkovic, S. J. (1981) Biochemistry 20, 337-344
14. Guillon, J.-M., Mechulam, Y., Schmitter, J.-M., Blanquet, S., and Fayat, G. (1992) J. Bacteriol. 174, 4294-4301
15. Inglese, J., Smith, J. M., and Benkovic, S. J. (1990) Biochemistry 29, 6678-6687
16. Blow, D. M., Birktoft, J. J., and Hartley, B. S. (1969) Nature 221, 337-340
17. Blow, D. M. (1997) Trends Biochem. Sci. 22, 405-408
18. Dodson, G., and Wlodawer, A. (1998) Trends Biochem. Sci. 23, 347-352
19. Liao, D.-I., Breddam, K., Sweet, R. M., Bullock, T., and Remington, S. J. (1992) Biochemistry 31, 9796-9812
20. Yuan, C., and Tsai, M.-D. (1999) Biochim. Biophys. Acta 1441, 215-222
21. Pathak, D., and Ollis, D. (1990) J. Mol. Biol. 214, 497-525
22. Cheah, E., Ashley, G. W., Gary, J., and Ollis, D. (1993) Proteins 16, 64-78
23. Schultz, L. W., Quirk, D. J., and Raines, R. T. (1998) Biochemistry 37, 8886-8898
24. McCall, K. A., Huang, C.-C., and Fierke, C. A. (2000) J. Nutr. 130, 1437S-1446S
25. Warren, M. S., Marolewski, A. E., and Benkovic, S. J. (1996) Biochemistry 35, 8855-8862
26. Shim, J. H., and Benkovic, S. J. (1998) Biochemistry 37, 8776-8782
27. Greasley, S. E., Yamashita, M. M., Cai, H., Benkovic, S. J., Boger, D. L., and Wilson, I. A. (1999) Biochemistry 38, 16783-16793
28. Almassy, R. J., Janson, C. A., Kan, C.-C., and Hostomska, Z. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 6114-6118
29. Chen, P., Schulze-Gahmen, U., Stura, E. A., Inglese, J., Jonson, D. L., Marolewski, A., Benkovic, S. J., and Wilson, I. A. (1992) J. Mol. Biol. 227, 283-292
30. Klein, C., Chen, P., Arevalo, J. H., Stura, E. A., Marolewski, A., Warren, M. S., Benkovic, S. J., and Wilson, I. A. (1995) J. Mol. Biol. 249, 153-175
31. Su, Y., Yamashita, M. M., Greasley, S. E., Mullen, C. A., Shim, J. H., Jennings, P. A., Benkovic, S. J., and Wilson, I. A. (1998) J. Mol. Biol. 281, 485-499
32. Schmitt, E., Blanquet, S., and Mechulam, Y. (1996) EMBO J. 15, 4749-4758
33. Newton, D. T., and Mangroo, D. (1999) Biochem. J. 339, 63-69
34. Rayl, E. A., Moroson, B. A., and Beardsley, G. P. (1996) J. Biol. Chem. 271, 2225-2233
35. Krupenko, S. A., and Wagner, C. (1999) J. Biol. Chem. 274, 35777-35784
36. Krupenko, S. A., and Wagner, C. (1998) Protein Expression Purif 14, 146-152
37. Krupenko, S. A., Horstman, D. A., Wagner, C., and Cook, R. J. (1995) Protein Expression Purif. 6, 457-464
38. Laemmli, U. K. (1970) Nature 227, 680-685
39. Burnette, W. N. (1981) Anal. Biochem. 112, 195-203
40. Krupenko, S. A., Wagner, C., and Cook, R. J. (1995) Biochem. J. 306, 651-655
41. Leary, J. J., Brigati, D. J., and Ward, D. C. (1983) Proc. Natl. Acad. Sci. U. S. A. 80, 4045-4049
42. Bradford, M. (1976) Anal. Biochem. 72, 248-254
43. Smith, G. K., Mueller, W. T., Benkovic, P. A., and Benkovic, S. J. (1981) Biochemistry 20, 1241-1245
44. Lindahl, R., and Evces, S. (1994) Biochem. Pharmacol. 33, 3383-3389
45. Eftink, M. R. (1997) Methods Enzymol. 278, 221-257
46. Chow, S. F., and Horowitz, P. M. (1985) J. Biol. Chem. 260, 15516-15521
47. Eftink, M. R., and Ghiron, C. A. (1981) Anal. Biochem. 114, 199-227
48. Peitsch, M. C. (1995) Bio/Technology 13, 658-660
49. Peitsch, M. C. (1996) Biochem. Soc. Trans. 24, 274-279
50. Guex, N., and Peitsch, M. C. (1997) Electrophoresis 18, 2714-2723
51. Eftink, M. R., and Shastry, M. C. R. (1997) Methods Enzymol. 278, 258-286
52. Semisotnov, G. V., Rodionova, N. A., Razgulyaev, O. I., Uversky, V. N., Gripas, A. F., and Gilmanshin, R. I. (1991) Biopolymers 31, 119-128
53. Kohno, T., Carmichael, D. F., Sommer, A., and Thompson, R. C. (1990) Methods Enzymol. 185, 187-195
54. Goldenberg, D. P. (1992) in Protein Folding (Creighton, T. E., ed) pp. 353-403, W. H. Freeman, New York
55. Alber, T. (1989) Annu. Rev. Biochem. 58, 765-798
56. Matthews, B. W. (1996) FASEB J. 10, 35-41
57. Kiefhaber, T., Rudolph, R., Kohler, H.-H., and Buchner, J. (1991) Bio/Technology 9, 825-829
58. Schein, C. H. (1990) Bio/Technology 8, 308-317
59. Nagy, P. L., Marolewski, A., Benkovic, S. J., and Zalkin, H. (1995) J. Bacteriol. 177, 1292-1298
60. Nagy, P. L., McCorkle, G. M., and Zalkin, H. (1993) J. Bacteriol. 175, 7066-7073
61. Nixon, A. E., Warren, M. S., and Benkovic, S. J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 1069-1073
62. McDonald, I. K., and Thorton, J. M. (1994) J. Mol. Biol. 238, 777-793
63. Steinmetz, C. G., Xie, P., Weiner, H., and Hurley, T. D. (1997) Structure 5, 701-711
64. Scott, D. L., White, S. P., Otwinowski, Z., Yuan, W., Gelb M. H., and Sigler, P. B. (1990) Science 250, 1541-1546
65. Krokan, H. E., Standal, R., and Slupphaug, G. (1997) Biochem. J. 325, 1-16
66. Cherbavaz, D. B., Lee, M. E., Stroud, R. M., and Koshland Jr., D. E. (2000) J. Mol. Biol. 295, 377-385
67. Wang, S., Stauffacher, C. V., and Van Etten, R. L. (2000) Biochemistry 39, 1234-1242
68. Brayer, G. D., Sidhu, G., Maurus, R., Rydberg, E. H., Braun, C., Wang, Y., Nguyen, N. T., Overall, C. M., and Withers, S. G. (2000) Biochemistry 39, 4778-4791
69. Feldman, R. I., and Weiner, H. (1972) J. Biol. Chem. 247, 267-272
70. Liu, Z.-J., Sun, Y.-J., Rose, J., Chung, Y.-J., Hsiao, C.-D., Chang, W.-R., Kuo, I., Perozich, J., Lindahl, R., Hempel, J., and Wang, B.-C. (1997) Nat. Struct. Biol. 4, 317-326
71. Cobessi, D., Tete-Favier, F., Marchal, S., Branlant, G., and Aubry, A. (2000) J. Mol. Biol. 300, 141-152
72. Smith, J. M., and Daum III, H. A. (1987) J. Biol. Chem. 262, 10565-10569
73. Meinnel, T., and Blanquet, S. (1994) J. Bacteriol. 176, 7387-7390
74. Steben, C., and Rabinowitz, J. C. (1986) J. Biol. Chem. 261, 4629-4637
75. Whitehead T. R., and Rabinowitz, J. C. (1988) J. Bacteriol. 170, 3255-3261