Very-long-chain fatty acid-containing phospholipids accumulate in fatty acid synthase temperature-sensitive mutant strains of the fission yeast Schizosaccharomyces pombe fas2/lsd1

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1532, Issue 3, 2001, Pages 223-233

  Yokoyama, Kazuaki ^a,f   Saitoh, Shigeaki ^b   Ishida, Mayuko ^c   Yamakawa, Yoshio ^d   Nakamura, Kazumi ^a   Inoue, Keizo ^a   Taguchi, Ryo ^c   Tokumura, Akira ^e   Nishijima, Masahiro ^d   Yanagida, Mitsuhiro ^b   Setaka, Morio ^a  

^a TEIKYO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^e UNIVERSITY OF TOKUSHIMA   (Japan)

^f UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Electrospray mass spectrometry; Fatty acid synthase; Melissate; Triacontanate; Two dimensional thin layer chromatography; Very long chain fatty acid

Indexed keywords

1 MELISSOYL 2 OLEOLYLGLYCERO 3 PHOSPHOCHOLINE; 1 MELISSOYL 2 OLEOLYLGLYCERO 3 PHOSPHOETHANOLAMINE; CHOLINE DERIVATIVE; ETHANOLAMINE DERIVATIVE; FATTY ACID SYNTHASE; PALMITIC ACID; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHOLIPID; PROTEIN; PROTEIN LSD1; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBUNIT; LIPID COMPOSITION; LIPID STORAGE; MISSENSE MUTATION; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; TEMPERATURE SENSITIVE MUTANT;

CARBON RADIOISOTOPES; CHROMATOGRAPHY, THIN LAYER; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; MUTATION; PHOSPHOLIPIDS; SCHIZOSACCHAROMYCES; TEMPERATURE;

SACCHAROMYCETALES; SCHIZOSACCHAROMYCES POMBE;

EID: 0035967796     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(01)00134-2     Document Type: Article

References (31)

1. Aberrant mitosis in fission yeast mutants defective in fatty acid synthetase and acetyl CoA carboxylase
2. Organelle structure, function, and inheritance in yeast: A role for fatty acid synthesis?
3. A role for unsaturated fatty acids in mitochondrial movement and inheritance
4. A yeast acetyl coenzyme A carboxylase mutant links very-long-chain fatty acid synthesis to the structure and function of the nuclear membrane-pore complex
5. The animal fatty acid synthase: One gene, one polypeptide, seven enzymes
6. Primary structure of the multifunctional α subunit protein of yeast fatty acid synthase from FAS2 gene sequence
7. Complementation of mutations and nucleotide sequence of FAS1 gene encoding β subunit of yeast fatty acid synthase
8. Clear differences in ceramide metabolism between glycosphingolipids and sphingomyelin in a human promyelocytic leukemia cell line HL-60 stimulated by a differentiation inducer
9. Changes in composition of newly synthesized sphingolipids of HeLa cells during the cell cycle. Suppression of sphingomyelin and higher-glycosphingolipid synthesis and accumulation of ceramide and glucosylceramide in mitotic cells
10. Simultaneous separation of lysophospholipids from the total lipid fraction of crude biological samples using two-dimensional thin-layer chromatography
11. 13C]malonyl-CoA
12. Fatty acid synthases from Mycobacterium phlei
13. Preparation of methyl esters of fatty acids for gas-liquid chromatography
14. Chemical analysis of acylation sites and species
15. A rapid method of total lipid extraction and purification
16. Phospholipid degradation in rat calcium ionophore-activated platelets is catalyzed mainly by two discrete secretory phospholipase As
17. Two-dimensional analysis of phospholipids by capillary liquid chromatography/electrospray ionization mass spectrometry
18. Molecular structure of the multifunctional fatty acid synthetase gene of Brevibacterium ammoniagenes: Its sequence of catalytic domains is formally consistent with a head-to-tail fusion of the two yeast genes FAS1 and FAS2
19. The palmityl binding sites of fatty acid synthetase from yeast
20. Reaction of yeast fatty acid synthetase with iodoacetamide
21. Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant
22. cDNA sequence of adrenodoxin reductase. Identification of NADP-binding sites in oxidoreductases
23. 2 (phosphatide acylhydrolase, EC 3.1.1.4) from porcine pancreas
24. Purification and properties of phospholipase A from porcine pancreas
25. Mitochondrial acyl carrier protein is involved in lipoic acid synthesis in Saccharomyces cerevisiae
26. Identification of a new nuclear gene (CEM1) encoding a protein homologous to a β-keto-acyl synthase which is essential for mitochondrial respiration in Saccharomyces cerevisiae
27. Effect of ethanol on the phospholipid and fatty acid content of Schizosaccharomyces pombe membranes
28. Peroxisomal fatty acid β-oxidation in relation to the accumulation of very long chain fatty acid in cultured skin fibroblasts from patients with Zellweger syndrome and other peroxisomal disorders
29. Very long-chain fatty acids in diagnosis, pathogenesis, and therapy of peroxisomal disorders
30. Molecular species of phosphatidylcholine containing very long chain fatty acids in human brain: Enrichment in X-linked adrenoleukodystrophy brain and diseases of peroxisome biogenesis brain
31. Mutant strains of Saccharomyces cerevisiae lacking sphingolipids synthesize novel inositol glycerophospholipids that mimic sphingolipid structure