α-B- and α-A-crystallin prevent irreversible acidification-induced protein denaturation

Biochemical and Biophysical Research Communications

Volumn 287, Issue 3, 2001, Pages 642-647

  Wang, Keyang ^a  

^a Teachers College   (United States)

Author keywords

Acidification; Molecular chaperone; Reactivation; Small heat shock protein; A crystallin; B crystallin; crystallin

Indexed keywords

ALPHA CRYSTALLIN; CHAPERONE; HEAT SHOCK PROTEIN; LUCIFERASE;

ACIDIFICATION; ANIMAL TISSUE; ARTICLE; CATTLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REACTIVATION; LENS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DENATURATION;

MAMMALIA;

EID: 0035964739     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5636     Document Type: Article

References (51)

1. The isolation and characterization of distinct macromolecular fractions
2. The lens proteins
3. The effect of phosphorylation on the structure of α-crystallin
4. 2 but phosphorylation has no effect on chaperone activity
5. αB subunit of lens-specific protein αB-crystallin is present in other ocular and non-ocular tissues
6. αB-crystallin is expressed in non-lenticular tissues and accumulates in Alexander's disease brain
7. Cardiac α-crystallin
8. Expression of the murine small heat shock proteins hsp25 and αB-crystallin in the absence of stress
9. Immunoreactive αA-crystallin in rat nonlenticular tissues detected with a sensitive immunoassay method
10. αA-Crystallin is expressed in non-ocular tissues
11. αA- and αB-crystallin in the retina
12. αB-Crystallin is a small heat shock protein
13. Hypertonic stress induces αB-crystallin expression
14. Four small Drosophila heat shock proteins are related to each other and to mammalian α-crystallin
15. α-Crystallin can function as a molecular chaperone
16. α-Crystallin, a molecular chaperone, forms a stable complex with carbonic anhydrase upon heat denaturation
17. Small heat shock proteins are molecular chaperones
18. The chaperone activity of bovine α-crystallin: Interaction with other lens crystallins in native and denatured states
19. Structure and in vitro molecular chaperone activity of cytosolic small heat shock proteins from pea
20. Binding of non-native protein to Hsp25 during heat shock creates a reservoir of folding intermediates for reactivation
21. A small heat shock protein stably binds heat-denatured model substrates and can maintain a substrate in a folding-competent state
22. The small heat-shock protein IbpB from Escherichia coli stabilizes stress-denatured proteins for subsequent refolding by a multichaperone network
23. Alpha-crystallin prevents irreversible protein denaturation and acts cooperatively with other HSPs to renature the stabilized partially denatured protein in an ATP dependent manner
24. αB-Crystallin expression in mouse 3T3 fibroblasts: Glucocorticoid responsiveness and involvement in thermal protection
25. αA-crystallin confers cellular thermoresistance
26. Sense and antisense modification of glial αB-crystallin production results in alterations of stress fiber formation and thermoresistance
27. Targeted disruption of the mouse and αA-crystallin gene induces cataract and cytoplasmic inclusion bodies containing the small heat shock protein αB-crystallin
28. Autosomal dominant congenital cataract associated with a missense mutation in the human alpha crystallin gene CRYAA
29. αB-crystallin gene knockout mice develop a severe, fatal phenotype late in life
30. A missense mutation in the αB-crystallin chaperone gene causes a desmin-related myopathy
31. The lens protein alpha-B-crystallin of the blind subterranean mole-rat: High homology with sighted mammals
32. Abundance and location of the small heat shock proteins HSP25 and alphaB-crystallin in rat and human heart
33. Ischemic acute renal failure induces differential expression of small heat shock proteins
34. Intracellular pH regulation in epithelial cells
35. Lactic acidosis and other mitochondrial disorders
36. Alteration of the cytosolic-mitochondrial distribution of high-energy phosphates during global myocardial ischemia may contribute to early contractile failure
37. Astrocytic acidosis in hyperglycemic and complete ischemia
38. Acid-induced changes of brain protein buffering
39. Acidosis induced necrosis and apotosis of cultured hippocampal neurons
40. Acidosis potentiates oxidative neuronal death by multiple mechanisms
41. α-Crystallin stabilizes actin filaments and prevents cytochalasin-induced depolymerization in a phosphorylation-dependent manner
42. Effect of stress on the pattern of phosphorylation of αA and αB in rat lens
43. 2 but phosphorylation has no effect on chaperone activity
44. Eye lens αA- and αB-crystallin: Complex stability versus chaperone-like activity
45. Effects of pH and KCl on the conformation of creatine kinase from rabbit muscle
46. ATP-dependent chaperoning activity of reticulocyte lysate
47. Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones
48. Characterization of Brucella suis clpB and clpAB mutants and participation of the genes in stress responses
49. HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria
50. Transgene overexpression of αB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion
51. Determination of crystallin aggregation: A new alternative method to assess ischemic damage of the heart