Mortality over two centuries in large pedigree with familial hypercholesterolaemia: Family tree mortality study

British Medical Journal

Volumn 322, Issue 7293, 2001, Pages 1019-1022

  Sijbrands, E J G ^a   Westendorp, R G J ^b   Defesche, J C ^a   De Meier, P H E M ^b   Smelt, A H M ^b   Kastelein, J J P ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ENVIRONMENTAL FACTOR; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; GENE MUTATION; GENETIC RISK; HETEROZYGOTE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NETHERLANDS; PEDIGREE; PRIORITY JOURNAL;

ADULT; AGED; FEMALE; HETEROZYGOTE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; MALE; MIDDLE AGED; MUTATION; NETHERLANDS; PEDIGREE; REGRESSION ANALYSIS; SEX FACTORS; SURVIVAL RATE;

EID: 0035962344     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Angina pectoris in hereditary xanthomatosis
2. Coronary artery disease in 116 kindred with familial type II hyperlipoproteinemia
3. Evidence that men with familial hypercholesterolemia can avoid early coronary death
4. Risk of fatal coronary heart disease in familial hypercholesterolaemia
5. Additional risk factors influence mortality in heterozygous familial hypercholesterolaemia
6. Hyperlipidemia in coronary heart disease. III. Evaluation of lipoprotein phenotypes of 156 genetically defined survivors of myocardial infarction
7. Relation of serum lipoprotein(a) concentration and apolipoprotein(a) phenotype to coronary heart disease in patients with familial hypercholesterolemia
8. Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia
9. Evidence for gene-environmental interactions in Utah families with hypertension, dyslipidaemia and early coronary heart disease
10. Mutations in the low density lipoprotein receptor gene of familial hypercholesterolemic patients detected by denaturing gradient gel electrophoresis and direct sequencing
11. Screening for familial hypercholesterolemia in the Netherlands: The first five years of experience
12. South African founder mutations in the low-density lipoprotein receptor gene causing familial hypercholesterolemia in the Dutch population
13. Mortality, in hereditary antithrombin-III deficiency - 1830 to 1989
14. Mortality and causes of death in families with the factor V Leiden mutation (resistance to activated protein C)
15. Competing mortality and progress against cancer
16. Low-density lipoprotein receptor-deficient mice are protected against lethal endotoxemia anal severe gram-negative infections
17. Familial hypercholesterolemia: A genetic and metabolic study
18. Ischaemic disease in men and women with familial hypercholesterolaemia and xanthomatosis. A comparative study of genetic and environmental factors in 274 heterozygous cases
19. Serum cholesterol and acute myocardial infarction: A case control study from the GISS1-2 trial
20. Intrafamilial variability in the clinical expression of familial hypercholesterolemia: Importance of risk factor determination for genetic counselling