Biochemical basis for the dominant inheritance of hypermethioninemia associated with the R264H mutation of the MAT1A gene. A monomeric methionine adenosyltransferase with tripolyphosphatase activity

Journal of Biological Chemistry

Volumn 276, Issue 17, 2001, Pages 13803-13809

  Pérez Mato, Isabel ^d   Sánchez del Pino, Manuel M ^d   Chamberlin, Margaret E ^b   Mudd, S Harvey ^c   Mato, José M ^a   Corrales, Fernando J ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; ENZYMES; GENES; MUTAGENESIS;

METHIONINE ADENOSYLTRANSFERASE;

BIOCHEMISTRY;

METHIONINE ADENOSYLTRANSFERASE; MUTANT PROTEIN; PHOSPHATASE; RECOMBINANT PROTEIN; S ADENOSYLMETHIONINE; TRIPHOSPHATASE; UNCLASSIFIED DRUG; ACID ANHYDRIDE HYDROLASE; ARGININE; HISTIDINE; METHIONINE;

AMINOACIDEMIA; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CATALYSIS; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME SUBUNIT; GEL PERMEATION CHROMATOGRAPHY; GENE MUTATION; HYPERMETHIONINEMIA; LIVER; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; SITE DIRECTED MUTAGENESIS; ANIMAL; BINDING SITE; BLOOD; CHEMISTRY; CHROMATOGRAPHY; DIMERIZATION; DOMINANT GENE; ENZYMOLOGY; EXON; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PHENOTYPE; PROTEIN BINDING; PROTEIN FOLDING; TIME;

ANIMALIA;

ACID ANHYDRIDE HYDROLASES; ANIMALS; ARGININE; BINDING SITES; CATALYSIS; CHROMATOGRAPHY; DIMERIZATION; EXONS; GENES, DOMINANT; HISTIDINE; HUMANS; KINETICS; LIVER; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENOTYPE; PROTEIN BINDING; PROTEIN FOLDING; RATS; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 0035958056     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.m009017200     Document Type: Article

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