Bioconversion of the anthracycline analogue desacetyladriamycin by recombinant DoxA, a P450-monooxygenase from Streptomyces sp. strain C5

Organic Letters

Volumn 3, Issue 15, 2001, Pages 2277-2279

  Walczak, Robbie J ^a,b   Hines, Jennifer V ^a,c   Strohl, William R ^a,d   Priestley, Nigel D ^a  

^a UNIVERSITY OF MONTANA   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c OHIO UNIVERSITY   (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

10 HYDROXYDESACETYLADRIAMYCIN; 10-HYDROXYDESACETYLADRIAMYCIN; ANTINEOPLASTIC ANTIBIOTIC; BACTERIAL PROTEIN; CYTOCHROME P450; DESACETYLADRIAMYCIN; DOXA PROTEIN, STREPTOMYCES PEUCETIUS; DOXORUBICIN; DRUG DERIVATIVE; MIXED FUNCTION OXIDASE; RECOMBINANT PROTEIN;

ARTICLE; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; HYDROXYLATION; METABOLISM; NUCLEAR MAGNETIC RESONANCE; STREPTOMYCES;

ANTIBIOTICS, ANTINEOPLASTIC; BACTERIAL PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; DOXORUBICIN; HYDROXYLATION; MIXED FUNCTION OXYGENASES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; RECOMBINANT PROTEINS; STREPTOMYCES;

EID: 0035954857     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol015998x     Document Type: Article

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