Pro-apoptotic interactions between XK469 and the peripheral benzodiazepine receptor

Cancer Letters

Volumn 168, Issue 2, 2001, Pages 141-144

  Kessel, David ^a   Horwitz, Jerome P ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Peripheral benzodiazepine receptor; PK11195; XK469

Indexed keywords

2 [4 (7 CHLORO 2 QUINOXALINYLOXY)PHENOXY]PROPIONIC ACID; ANTINEOPLASTIC AGENT; ASSURE; BENZODIAZEPINE RECEPTOR; HERBICIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; STAUROSPORINE; UNCLASSIFIED DRUG; XK 469;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CULTURE; CELL LINE; CHIRALITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG RECEPTOR BINDING; MOUSE; MURINE LEUKEMIA; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING, COMPETITIVE; CELL NUCLEUS; INTRACELLULAR MEMBRANES; ISOQUINOLINES; LEUKEMIA L1210; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; QUINOXALINES; RECEPTORS, GABA-A; STAUROSPORINE; STEREOISOMERISM;

EID: 0035954821     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00518-3     Document Type: Article

References (8)

1. Preclinical antitumor activity of XK469 (NSC 656889) concentration dependent toxicity from 0.5-30 μg/mL
2. Preclinical antitumor efficacy of analogs of XK469: Sodium-(2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]propionate
3. Mitochondrial photodamage and PDT-induced apoptosis
4. Mechanism of phototoxicity catalyzed by two porphycenes
5. Photodynamic therapy: A mitochondrial inducer of apoptosis
6. XK469, a selective topoisomerase IIβ beta poison (Tox at 1-5 mM)
7. Porphyrins are endogenous ligands for the mitochondrial (peripheraltype) benzodiazepine receptor
8. PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection