The influence of GSTM1 null genotype on susceptibility to in vitro oxidative stress

Toxicology

Volumn 157, Issue 3, 2001, Pages 195-205

  Onaran, Ilhan ^a,b   Güven, Gülgün ^a   Ozaydin, Ahmet ^a   Ulutin, Turgut ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b Hi̧zal Apt No:2 D:3 ^*  (Turkey)

Author keywords

Benzo(a)pyrene; Cumene hydroperoxide; Glutathione S transferase; Lymphocyte; Polymorphism

Indexed keywords

BENZO[A]PYRENE; CARBONYL DERIVATIVE; CUMENE HYDROPEROXIDE; FLUORESCEIN DERIVATIVE; GLUTATHIONE TRANSFERASE; MALONALDEHYDE; OXIDIZING AGENT;

ADULT; ARTICLE; CELL GROWTH; CELL KILLING; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GENETIC SUSCEPTIBILITY; GENOTOXICITY; GENOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; LYMPHOCYTE; MALE; MICRONUCLEUS; OXIDATIVE STRESS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BENZENE DERIVATIVES; BENZO(A)PYRENE; CELLS, CULTURED; FEMALE; GENOTYPE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; LIPID PEROXIDATION; LYMPHOCYTES; MALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; OXIDATIVE STRESS;

EID: 0035951625     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00358-9     Document Type: Article

References (36)

1. Genetic heterogeneity of the human glutathione transferases: A complex of gene families
2. Detection of picomoles of hydroperoxides using a fluorescent dichlorofluorescein assay
3. Free-radical chemistry of cigarette smoke and its toxicological implications
4. Determination of glutathione and glutathione disulfide using glulathione reductase and 2-vinylpiridine
5. Lipid peroxidation and antioxidants as biomarkers of tissue damage
6. Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer
7. Characterization and applicability of a cytotoxicity assay determining growth inhibition after a 1-h treatment with xenobiotics in human cell culture
8. Suppression of the invitro humoral response of mouse splenocytes by benzo(a)pyrene metabolites and inhibition of benzo(a)pyrene-induced immunosuppression by alpha-napthoflavine
9. Genoprotection by UDP-Glucuronosyltransferases in peroxidase-dependent, reactive oxygen species-mediated micronucleus initiation by the carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and benzo(a)pyrene
10. Effects of peroxides on rodent skin: Epidermal hyperplasia and promotion
11. Deficiency of glutathione S-transferases T1 and M1 as heritable factors of increased cutaneous UV sensitivity
12. Determination of carbonyl content in oxidatively modified proteins
13. Age and gender dependent levels of glutathione and glutathione S-transferases in human lymphocytes
14. Identification of genes differentially expressed in vascular smooth muscle cells following benzo(a)pyrene challenge: Implications for chemical atherogenesis
15. Identification of three classes of cytosolic glutathione transferase common to several mammalian: Correlation between structural data and enzymatic properties
16. A simple salty out procedure for extracting DNA from human nucleated cells
17. Effects of benzo(a)pyrene on concanavallin A-stimulated human peripheral blood mononuclear cells in-vitro: Inhibition of proliferation but no effects on parameters related to the G1 phase of the cell cycle
18. Environmental air pollution and DNA adducts in Copenhagen bus drivers - Effect of GSTM1 and NAT2 genotypes on adduct levels
19. Are individuals with glutathione S-transferase GSTT1 null genotype more susceptible to in vitro oxidative damage?
20. Stimulation of hydroperoxide generation in mouse skins treated with tumor-promoting or carcinogenic agents in vivo and in vitro
21. Glutathione S-transferases: Gene structure, regulation, and biological function
22. Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility - A review
23. Epithelial ovarian cancer: Influence of polymorphism at the glutathione S-transferase GSTM1 and GSTT1 loci on p53 expression
24. The role of human glutathione transferases and epoxide hydrolases in the metabolism of xenobiotics
25. The hereditary transmission of high glutathione transferase activity towards trans-stilbene oxide in human mononuclear leukocytes
26. Glutathione S-transferases of human lung: Characterization and evaluation of the protective role of the (-class isozymes against lipid peroxidation
27. Redox regulation of signal transduction: Tyrosine phosphorylation and calcium flux
28. Free radicals of benzo(a)pyrene and derivatives
29. Glutathione peroxidase activity in various types of blood cells in multiple sclerosis
30. Inter-individual variability of human hepatic glutathione S-transferase isozymes assessed by inhibitory capacity
31. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione
32. Inactivation of enzymes of the glutathione antioxidant system by treatment of cultured human keratinocytes with peroxides
33. Gene structure, expression and chromosomal localization of murine theta class glutathione mGSTT1-1
34. Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage
35. Cumene hydroperoxide-induced chemiluminecence in human erythrocytes: Effect of antioxidants and sulfhydryl compounds
36. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer