Antioxidant defense disruption by polycyclic aromatic hydrocarbons-coated onto Fe2O3 particles in human lung cells (A549)

Toxicology

Volumn 166, Issue 3, 2001, Pages 129-137

  Garçon, Guillaume ^a,b   Zerimech, Farid ^c   Hannothiaux, Marie Hélène ^a   Gosset, Pierre ^d   Martin, Annie ^c   Marez, Thierry ^a   Shirali, Pirouz ^a,b  

^a UNIV LILLE   (France)

^b UNIVERSITÉ DU LITTORAL CÔTE D OPALE   (France)

^c LILLE UNIVERSITY HOSPITAL   (France)

^d Hôpital Saint Vincent   (France)

Author keywords

A549 cells; Benzo(a)pyrene; Fe2O3; Oxidative stress; Pyrene

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BENZO[A]PYRENE; FERRIC OXIDE; FREE RADICAL; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MALONALDEHYDE; POLYCYCLIC AROMATIC HYDROCARBON; SUPEROXIDE DISMUTASE;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXPOSURE; HOMEOSTASIS; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LUNG ALVEOLUS CELL; LUNG INJURY; OXIDATIVE STRESS; PRIORITY JOURNAL;

EID: 0035949810     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00461-9     Document Type: Article

References (36)

1. Simultaneous determination of retinol, α-tocopherol and β-carotene in serum by isocratic high performance liquid chromatography
2. Evaluation of methods of coenzyme activation of erythrocyte enzymes for detection of deficiency of vitamins B1, B2 and B6
3. Lipid peroxidation coupled co-oxygenation of benzo(a)pyrene and benzo(a)pyrene-7, 8-dihydrodiol in human term placental microsomes
4. Central role of radical cations in metabolic activation of polycyclic aromatic hydrocarbons
5. Mortality of iron miners in Lorraine (France): Relations between lung functions and respiratory symptoms and subsequent mortality
6. Benzo(a)pyrene coated ferric oxide and aluminium oxide particles: Uptake, metabolism and DNA binding in hamster pulmonary alveolar macrophages and tracheal epithelial cells in vitro
7. Oxidants, antioxidants, and respiratory tract lining fluids
8. Biomarkers of free radical damage: Applications in experimental animals and in humans
9. Antioxidant defense systems: The role of carotenoids, tocopherols and thiols
10. 3 particles: Assessment of cellular membrane damage and antioxidant system disruption in human epithelial lung cells (L132) in culture
11. Particle-associated polycyclic aromatic hydrocarbons - A reappraisal of their possible role in pulmonary carcinogenesis
12. Antioxidant gene expression in rat lung after exposure to cigarette smoke
13. Influence of the dose levels of cocarcinogen ferric oxide on the metabolism of benzo(a)pyrene by pulmonary alveolar macrophages in suspension culture
14. Comparisons of catalytic selectivity of cytochrome P450 subfamily enzymes from different species
15. Effect of mineral particles containing iron on primary cultures of rabbit tracheal epithelial cells: Possible implication of oxidative stress
16. Induction of oxidative DNA damage by ferric iron in mammalian cells
17. Oxidative stress to DNA, protein, and antioxidant enzymes (superoxide dismutase and catalase) in rats treated with benzo(a)pyrene
18. Primary and immortalized (BEAS 2B) human bronchial epithelial cells have significant antioxidative capacity in vitro
19. Non-induced oxidative stress and glutathione metabolism in rodent and human cells
20. Antioxidant enzymes and their implications in pathophysiologic processes
21. Superoxide dismutase. An enzymatic function for erythrocuprein (hemocyprein)
22. Glutathione and glutathione-dependent enzymes in cancer drug resistance
23. Risk of lung cancer among iron ore miners: A proportional mortality study of 1,075 deceased miners in Lorraine, France
24. Iron-induced tissue damage and cancer: The role of reactive oxygen species-free radicals
25. Studies on the quantitative and the qualitative characterization of erythrocyte glutathione peroxidase
26. Iron and activated oxygen species in biology: The basic chemistry
27. Catalase and glutathione reductase protection of human alveolar macrophage during oxidant exposure in vitro
28. The role of iron in oxygen-mediated toxicities
29. 2 on arachidonic acid metabolites in cultured human lung cells (L132 cell line)
30. Glutathione and its role in cellular functions
31. Measurement of protein using bicinchoninic acid
32. Compartimentation of glutathione: Implications for the study of toxicity and disease
33. The mechanism of iron (III) stimulation of lipid peroxidation
34. The effects of cocarcinogen, ferric oxide, on the metabolism of benzo(a)pyrene in the isolated perfused lung
35. Influence of particle dose on the cytotoxicity of hamster and rat pulmonary alveolar macrophage in vitro
36. A critical appraisal of intratracheal instillation of benzo(a)pyrene to Syrian golden hamsters as a model in respiratory tract carcinogenesis