Determination of fluvastatin and its five metabolites in human plasma using simple gradient reversed-phase high-performance liquid chromatography with ultraviolet detection

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 760, Issue 1, 2001, Pages 17-25

  Nakashima, Akinori ^a   Saxer, Christoph ^a   Niina, Miyuki ^a   Masuda, Naoki ^a   Iwasaki, Kazuhide ^a   Furukawa, Kotaro ^b  

^a NOVARTIS PHARMA K K   (Japan)

^b CHEMICALS EVALUATION AND RESEARCH INSTITUTE   (Japan)

Author keywords

Fluvastatin; HMG CoA reductase; Metabolites

Indexed keywords

BIOASSAY; CELLS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET DETECTORS;

HUMAN PLASMA;

METABOLITES;

5 HYDROXYFLUINDOSTATIN; 6 HYDROXYFLUINDOSTATIN; 9 ANTHRONITRILE; ANTHRACENE DERIVATIVE; BENZOPHENONE; DESISOPROPYLPROPIONIC ACID; DRUG METABOLITE; FLUINDOSTATIN; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STABILITY; DRUG STRUCTURE; HUMAN; MALE; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TEMPERATURE DEPENDENCE; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

ANTICHOLESTEREMIC AGENTS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FATTY ACIDS, MONOUNSATURATED; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 0035949195     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(01)00250-X     Document Type: Article

References (13)