Immunohistochemical localization of trichloroacylated protein adducts in tetrachloroethene-treated mice

Journal of Toxicology and Environmental Health - Part A

Volumn 63, Issue 2, 2001, Pages 145-157

  Green, Steven M ^a,b   Firoze Khan, M ^a   Kaphalia, Bhupendra S ^a   Ansari, G A S ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b DOW CORNING CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; PROTEIN; TETRACHLOROETHYLENE;

ACYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL VEIN; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LIVER LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TOXICOKINETICS; WESTERN BLOTTING;

ACYLATION; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPATOCYTES; IMMUNOHISTOCHEMISTRY; LIVER; MICE; MICE, INBRED MRL LPR; PROTEIN BINDING; RANDOM ALLOCATION; SOLVENTS; TETRACHLOROETHYLENE; TISSUE DISTRIBUTION;

EID: 0035947473     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390151126487     Document Type: Article

References (25)

1. Agency for Toxic Substances and Disease Registry. 1997. Toxicological Profile for Tetrachloroethylene (Update). Department of Health and Human Services, ATSDR, Atlanta, GA.
2. Birner, G., Richling, C, Henschler, D., Anders, M. W., and Dekant, W. 1994. Metabolism of tetrachloroethene in rats: Identification of n-epsilon-(dichloroacetyl)-L-lysine and n-epsilon-(trichloroacetyl)-L-lysine as protein adducts. Chem. Res. Toxicol 7 :724-732.
3. Conn, J. A., Tsai, L., Friguet, B., and Szzweda, L. I. 1996. Chemical characterization of a protein-4-hydroxy-2-nonenal cross-link: Immunochemical detection in mitochondria exposed to oxidative stress. Arch. Biochem. Biophys. 328:158-164.
4. Dekant, W., and Henschler, D. 1999. Organ-specific carcinogenicity of haloalkenes mediated by glutathione conjugation. J. Cancer Res. Clin. Oncol. 125:174-181.
5. Dekant, W., Birner, G., Werner, M., and Parker, J. 1998. Glutathione conjugation of perchloroethene in subcellular fractions from rodent and human liver and kidney. Chem. Biol. Interact. 116:31-43.
6. Goldsworthy, T. L., Lyght, O., Burnett, V. L., and Popp, J. A. 1988. Potential role of α-2μ-globulin, protein droplet accumulation, and cell replication in the renal carcinogenicity of rats exposed to trichloroethylene, perchloroethylene, and pentachloroethane. Toxicol. Appl. Pharmacol. 96:367-379.
7. Halmes, N. C., McMillan, D. C., Oatis, J. E. J., and Pumford, N. R. 1996. Immunochemical detection of protein adducts in mice treated with trichloroethylene. Chem. Res. Toxicol. 9:451-456.
8. Harlow, E., and Lane, D. 1999. Staining tissues. In Using antibodies, ed. J. Cuddihy, pp. 151-220. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
9. Hinson, J. A., and Roberts, D. W. 1992. Role of covalent and noncovalent interactions in cell toxicity: Effects on proteins. Annu. Rev. Pharmacol. Toxicol. 32:471-510.
10. Ikeda, M., Ohtsuji, H., Imamura, T., and Komoike, Y. 1972. Urinary excretion of total trichloro-compounds, trichloroethanol, and trichloroacetic acid as a measure of exposure to trichloroethylene and tetrachloroethylene. Br. J. Ind. Med. 29:328-333.
11. Kenna, J, G., Neuberger, J., and Williams, R. 1984. An enzyme-linked immunosorbent assay for detection of antibodies against halothane-altered hepatocyte antigens. J. Immunol. Methods 75: 3-14.
12. Khan, M. F., Kaphalia, B. S., Prabhakar, B. H., Kanz, M. F., and Ansari, G. A. S. 1995. Trichloroethene-induced autoimmune response in female MRL +/+ mice. Toxicol. Appl. Pharmacol. 134: 155-160.
13. Khan, M. F., Kaphalia, B. S., and Ansari, G. A. S. 1997. Time-dependent autoimmune response of dichloroacetyl chloride in female MRL +/+ mice. Immunopharmacol. Immunotoxicol. 19:265-277.
14. Kylin, B., Reichard, H., Sumegi, I., and Yllner, S. 1962. Hepatotoxic effect of tri-and tetrachloroethylene on mice. Nature 163:395.
15. Lockey, J. E., Kelly, C. R., Cannon, G. W., Colby, T. V., Aldrich, V., and Livingston, G. K. 1987. Progressive systemic sclerosis associated with exposure to trichloroethylene. J. Occup. Med. 29: 493-496.
16. Mutti, A., Alinovi, R., Bergamaschi, E., Biagini, C., Cavazzini, S., Franchini, I., Lauwerys, R. R., Bernard, A. M., Roels, H., Gelpi, E., Rosello, J., Ramis, I., Price, R. G., Taylor, S. A., DeBroe, M., Nuyts, G. D., Stolte, H., Fels, L. M., and Herbort, C. 1992. Nephropathies and exposure to perchloroethylene in dry-cleaners. Lancet 340:189-193.
17. Odum, J., Green, T., Foster, J. R., and Hext, P. M. 1988. The role of trichloroacetic acid and peroxisome proliferation in the differences in carcinogenicity of perchloroethylene in the mouse and rat. Toxicol. Appl. Pharmacol. 92:103-112.
18. Pahler, A., Birner, G., Parker, J., and Dekant, W. 1998. Generation of antibodies to di-and trichloroacetylated proteins and immunochemical detection of protein adducts in rats treated with perchloroethene. Chem. Res. Toxicol. 11:995-1004.
19. Pahler, A., Parker, J., and Dekant, W. 1999. Dose-dependent protein adduct formation in kidney, liver, and blood of rats and in human blood after perchloroethene inhalation. Toxicol. Sci. 48:5-13.
20. Saihan, E. M., Burton, J. L., and Wheaton, K. W. 1978. A new syndrome with pigmentation, scleroderma, gynaecomastia, Raynaud's phenomenon and peripheral neuropathy. Br. J. Dermatol. 99: 437-440.
21. Schallenberg, E., and Calvin, M. 1955. Ethyl thioltrifluoroacetate as an acylating agent with particular reference to peptide synthesis. J. Am. Chem. Soc. 77:2779-2783.
22. Schreiber, J. S. 1997. Transport of organic chemicals to breast milk; Tetrachloroethene case study. In Environmental toxicology and pharmacology of human development, eds. S. Kacew and G. H. Lamber, pp. 95-143. Washington, DC: Taylor & Francis.
23. Sparrow, G. P. 1977. A connective tissue disorder similar to vinyl chloride disease in a patient exposed to perchloroethylene. Clin. Exp. Dermatol. 2:17-22.
24. Uetrecht, J. P. 1988. Mechanism of drug-induced lupus. Chem. Res. Toxicol. 1:133-143.
25. Veltman, G., Lange, C. E., June, S., Stein, C., and Bachner, U. 1975. Clinical manifestations and course of vinyl chloride disease. Ann. NY Acad. Sci. 246:6-17.