Fortification of flour with folic acid: A controlled field trial is needed

BMJ

Volumn 323, Issue 7323, 2001, Pages 1198-1199

  Wharton, Brian ^a   Booth, Ian ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID;

CONTROLLED STUDY; DIET SUPPLEMENTATION; EDITORIAL; FLOUR; FOLIC ACID DEFICIENCY; HUMAN; MATERNAL NUTRITION; NEURAL TUBE DEFECT; PRIORITY JOURNAL; VITAMIN SUPPLEMENTATION;

CONTROLLED CLINICAL TRIALS; FEMALE; FLOUR; FOLIC ACID; FOOD, FORTIFIED; HUMANS; NEURAL TUBE DEFECTS; PREGNANCY; PRENATAL CARE;

EID: 0035944728     PISSN: 09598138     EISSN: 14685833     Source Type: Journal    
DOI: 10.1136/bmj.323.7323.1198     Document Type: Editorial

References (15)

1. Hibbard ED, Smithells RW. Folic acid metabolism and human embryopathy. Lancet 1968; 1: 1254.
2. Smithells RW, Nevin NC, Seller MJ, Shepppard S, Read AP, Fielding DI, et al. Further experience of vitamin supplementation for prevention of neural tube defect recurrences. Lancet 1983; 1: 127–131.
3. MRC Vitamin Study Research Group. Prevention of neural tube defects: results of the Medical Research Council vitamin study. Lancet 1991; 338: 131–137.
4. Czeizel AE, Dudas I. Prevention of the first occurrence or neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327: 1832–1835.
5. Hall JG, Solhedin F. Folate and its ramifications Advances in Pediatrics 1998; 45: 1–35.
6. Department of Health. Folic acid and the prevention of disease. London: Stationery Office, 2000: 1–101.
7. US Department of Health and Human Services, Food and Drug Administration. Food standards: amendment of the standards of identity for enriched grain products to require addition of folic acid. Fed Reg 1993; 58: 53306–53312.
8. Wharton BA, Darke SJ. Infantile hypercalcaemia. In: Jelliffe EFP,Jelliffe DB,eds. Adverse effects of foods. New York: Plenum, 1982: 397–404.
9. McPhail AP, Bothwell TH. Fortification of the diet as strategy for prevention of iron deficiency. Acta Paediatr 1989; 361(suppl):114–124.
10. Jaques PF, Selhub J, Bostom AG, Wilson PWF, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999; 340: 1449–1454.
11. Honein MA, Paulozzi LJ, Mathews TJ, Erickson JD, Lee-Yang C W. Impact of folic acid fortification of the US food supply on the occurrence of neural tube defects. JAMA 2001; 285: 2981–2986.
12. Mills JL, England L. Food fortification to prevent neural tube defects. Is it working? JAMA 2001; 285: 3022–3023.
13. Mills JL. Fortification of foods with folic acid—how much is enough? N Engl J Med 2000; 342: 1442–1445.
14. Lumley J, Watson L, Watson M, Bower C. Periconceptional supplementation with folate and/or multivitamins for preventing neural tube defects. Cochrane Database Syst Rev 2000; 2: CD001056.
15. Botting B. The health of our children. London: HMSO, 1995: 148–158. (DS No 11.)