The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity: Roles of residues in the fourth intracellular and third transmembrane domains

Journal of Biological Chemistry

Volumn 276, Issue 12, 2001, Pages 8785-8792

  Leeb Lundberg, L M Fredrik ^a   Kang, Dong Soo ^b   Lamb, Maria E ^b   Fathy, Dana B ^b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS; HYDROLYSIS; MUTAGENESIS; PROTEINS;

INTRACELLULAR DOMAINS;

BIOCHEMISTRY;

ALANINE; ASPARAGINE; BRADYKININ B1 RECEPTOR; BRADYKININ B2 RECEPTOR; EPITOPE; G PROTEIN COUPLED RECEPTOR; LIGAND; MEMBRANE RECEPTOR; MUTANT PROTEIN; PHOSPHATIDYLINOSITIDE; PROTEIN INHIBITOR; SERINE; THREONINE; BRADYKININ RECEPTOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL STRAIN; CONTROLLED STUDY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; INTERNALIZATION; NOCICEPTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG POTENTIATION; METABOLISM; MOLECULAR GENETICS; MUTAGENESIS; PROTEIN BINDING; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ASPARAGINE; CELL LINE; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PROTEIN BINDING; RECEPTOR, BRADYKININ B1; RECEPTORS, BRADYKININ; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035937808     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007396200     Document Type: Article

References (42)

1. Hess, J. F., Borkowski, J. A., Young, G. S., Strader, C. D., and Ransom, R. W. (1992) Biochem. Biophys. Res. Commun. 184, 260-268
2. Menke, J. G., Borkowski, J. A., Bierilo, K. K., MacNeil, T., Derrick, A. W., Schneck, K. A., Ransom, R. W., Strader, C. D., Linemeyer, D. L., and Hess, J. F. (1994) J. Biol. Chem. 269, 21583-21586
3. Regoli, D., and Barabe, J. (1980) Pharmacol. Rev. 32, 1-46
4. Proud, D., and Kaplan, A. P. (1988) Annu. Rev. Immunol. 6, 49-83
5. Bhoola, K. D., Figueroa, C. D., and Worthy, K. (1992) Pharmacol. Rev. 44, 1-80
6. Dray, A., and Perkins, M. (1993) Trends Neurosci. 16, 99-104
7. Marceau, F., Hess, J. F., and Bachvarov, D. R. (1998) Pharmacol. Rev. 50, 357-386
8. Phagoo, S. B., Poole, S., and Leeb-Lundberg, L. M. F. (1999) Mol. Pharmacol. 56, 325-333
9. Davis, A. J., and Perkins, M. N. (1994) Br. J. Pharmacol. 113, 63-68
10. Schanstra, J. P., Bataille, E., Marin, Castano, M. E., Barascud, Y., Hirtz, C., Pesquero, J. B., Pecher, C., Gauthier, F., Girolami, J. P., and Bascands, J. L. (1998) J. Clin. Invest. 101, 2080-2091
11. Steranka, L. R., Manning, D. C., DeHaas, C. J., Ferkany, J. W., Borosky, S. A., Connor, J. R., Vavrek, R. J., Stewart, J. M., and Snyder, S. H. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 3245-3249
12. Dray, A. (1997) Can. J. Physiol. Pharmacol. 75, 704-712
13. Farmer, S. G., McMillan, B. A., Meeker, S. N., and Burch, R. M. (1991) Agents Actions 34, 191-193
14. Pesquero, J. B., Araujo, R. C., Heppenstall, P. A., Stucky, C. L., Silva, J. A., Jr., Walther, T., Oliveira, S. M., Pesquero, J. L., Paiva, A. C. M., Calixto, J. B., Lewin, G., and Bader, M. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 8140-8145
15. Bascands, J. L., Pecher, C., Rouaud, S., Emond, C., Tack, J. L., Bastie, M. J., Burch, R., Regoli, D., and Girolami, J. P. (1993) Am. J. Physiol. 264, F548-F556
16. Mathis, S. A., Criscimagna, N. L., and Leeb-Lundberg, L. M. F. (1996) Mol. Pharmacol. 50, 128-129
17. Ward, P. E. (1991) in Bradykinin Antagonists (Burch, R. M., ed) pp. 147-170, Marcel Dekker, Inc., New York
18. Coughlin, S. R. (1994) Curr. Opin. Cell Biol. 6, 191-197
19. Laue, L., Chan, W. Y., Hsueh, A. J., Kudo, M., Hsu, S. Y., Wu, S. M., Blomberg, L., and Cutler, G. B., Jr. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 1906-1910
20. Parma, J., Duprez, L., Van Sande, J., Cochaux, P., Gervy, C., Mockel, J., Dumont, J., and Vassart, G. (1993) Nature 365, 649-651
21. Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M. C., and Cesarman, E. (1997) Nature 385, 347-350
22. Scheer, A., and Cotecchia, S. (1997) J. Recept. Signal Transduct. Res. 17, 57-73
23. Marie, J., Koch, C., Pruneau, D., Paquet, J.-L., Groblewski, T., Larguier, R., Lombard, C., Deslauriers, B., Maigret, B., and Bonnafous, J.-C. (1999) Mol. Pharmacol. 55, 92-101
24. Groblewski, T., Maigret, B., Larguier, R., Lombard, C., Bonnafous, J.-C., and Marie, J. (1997) J. Biol. Chem. 272, 1822-1826
25. Perez, D. M., Hwa, J., Gaivin, R., Mathur M., Brown, F., and Graham, R. M. (1996) Mol. Pharmacol. 49, 112-122
26. Cohen, G. B., Oprian, D. D., and Robinson, P. R. (1992) Biochemistry 31, 12592-12601
27. Matus-Leibovitch, N., Nussenzveig, D. R., Gershengorn, M. C., and Oron, Y. (1995) J. Biol. Chem. 270, 1041-1047
28. Hasegawa, H., Negishi, M., and Ichikawa, A. (1996) J. Biol. Chem. 271, 1857-1860
29. Mary, S., Gomeza, J., Prezeau, L., Bockaert, J., and Pin, J.-P. (1998) J. Biol. Chem. 273, 425-432
30. Claeysen, S., Sebben, M., Becamel, C., Bockaert, J., and Dumuis, A. (1999) J. Biol. Chem. 55, 910-920
31. Fathy, D. B., Leeb, T., Mathis, S. A., and Leeb-Lundberg, L. M. F. (1999) J. Biol. Chem. 274, 29603-29606
32. Pizard, A., Blaukat, A., Muller-Esterl, W., Ahlenc-Gelas, F., and Rajerison, R. M. (1999) J. Biol. Chem. 274, 12738-12747
33. Fathy, D. B., Mathis, S. A., Leeb, T., and Leeb-Lundberg, L. M. F. (1998) J. Biol. Chem. 273, 12210-12218
34. De Weerd, W. F. C., and Leeb-Lundberg, L. M. F. (1997) J. Biol. Chem. 272, 17858-17866
35. Blaukat, A., Herzer, K., Schroeder, C., Bachmann, M., Nash, N., and Muller-Esterl, W. (1999) Biochemistry 38, 1300-1309
36. Samama, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 4625-4636
37. Kenakin, T. P. (1996) Pharmacol. Rev. 48, 413-463
38. Austin, K. E., Faussner, A., Robinson, H. E., Chakravarty, S., Kyle, D. J., Bathon, J. M., and Proud, D. (1997) J. Biol. Chem. 272, 11420-11425
39. Bachvarov, D. R., Landry, M., Houle, S., Pare, P., and Marceau, F. (1998) Gastroenterology 115, 1045-1048
40. Bachvarov, D. R., Landry, M., Pelletier, I., Chevrette, M., Betard, C., Houde, I., Bergeron, J., Lebel, M., and Marceau, F. (1998) J. Am. Soc. Nephrol. 9, 598-604
41. Regoli, D. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 7676-7677
42. Leeb-Lundberg, L. M. F., Mathis, S. A., and Herzig, M. C. S. (1994) J. Biol. Chem. 269, 25970-25973