An easy producible new oral hydrocolloid drug delivery system with a late burst in the release profile

International Journal of Pharmaceutics

Volumn 216, Issue 1-2, 2001, Pages 165-169

  Freichel, Oliver L ^a   Lippold, Bernhard C ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Burst effect; Drug delivery; Erosion; HPMCAS HF; Hydrocolloid tablets; MHEC; pH control; pH dependent solubility

Indexed keywords

DRUG ADDITIVE; HYDROXYETHYLMETHYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; PENTOXIFYLLINE; UNCLASSIFIED DRUG;

ACCELERATION; ARTICLE; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG STABILITY; ENTERIC COATED TABLET; HYDROCOLLOID; HYDRODYNAMICS; IONIC STRENGTH; PH; PRIORITY JOURNAL; TABLET COMPRESSION; TABLET FORMULATION;

ADMINISTRATION, ORAL; COLLOIDS; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; ENZYME INHIBITORS; HYDROGEN-ION CONCENTRATION; METHYLCELLULOSE; PENTOXIFYLLINE; TABLETS;

EID: 0035937557     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00586-5     Document Type: Article

References (7)

1. A new oral erosion controlled drug delivery system with a late burst in the release profile
2. Influence of ionic strength on matrix-integrity and drug release from hydroxypropyl cellulose compacts
3. Drug release from hydrocolloid embeddings with high or low susceptibility to hydrodynamic stress
4. Zero-order drug release from hydrocolloid matrices
5. Dissociation constants of enteric coating materials
6. Polymer particle erosion controlling drug release. 1. Factors influencing drug release and characterization of the release, mechanism