Role of adenosine and glycogen in ischemic preconditioning of rat hearts

European Journal of Pharmacology

Volumn 414, Issue 1, 2001, Pages 55-62

  De Jonge, Robert ^a   De Jong, Jan W ^a   Giacometti, Diana ^b   Bradamante, Silvia ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

(Rat); 13C NMR; 31P NMR (nuclear magnetic resonance); Adenosine A1 receptor; Glycogen; Ischemia; Ischemic preconditioning

Indexed keywords

2 CHLORO 6 N CYCLOPENTYLADENOSINE; 8 (4 SULFOPHENYL)THEOPHYLLINE; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; GLYCOGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GLYCOGENOLYSIS; HEART INFARCTION PREVENTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; GLYCOGEN; HYDROGEN-ION CONCENTRATION; ISCHEMIC PRECONDITIONING, MYOCARDIAL; MALE; MYOCARDIUM; PHOSPHATES; PHOSPHOCREATINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P1; THEOPHYLLINE;

EID: 0035936863     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00875-X     Document Type: Article

References (47)

1. Myocardial glycogen depletion cannot explain the cardioprotective effects of ischemic preconditioning in the rat heart
2. Attenuation of postischaemic dysfunction by ischaemic preconditioning is not mediated by adenosine in the isolated rat heart
3. Preconditioning ischemia time determines the degree of glycogen depletion and infarct size reduction in rat hearts
4. Protective activity of the spin trap tert-butyl-alpha-phenyl nitrone (PBN) in reperfused rat heart
5. Intracellular magnesium homeostasis is involved in the functional recovery of preconditioned rat heart
6. NMR evaluation of changes in myocardial high energy metabolism produced by repeated short periods of ischemia
7. Interstitial fluid (ISF) adenosine during exogenous adenosine administration in the isolated rabbit heart
8. 3 receptors in protection of isolated human atrial muscle against simulated ischaemia
9. 31P NMR study in the isolated rat heart
10. Improved functional recovery by ischaemic preconditioning is not mediated by adenosine in the globally ischaemic isolated rat heart
11. The obligate role of protein kinase C in mediating clinically accessible cardiac preconditioning
12. Is a high glycogen content beneficial or detrimental to the ischemic rat heart? A controversy resolved
13. Importance of metabolic inhibition and cellular pH in mediating preconditioning contractile and metabolic effects in rat hearts
14. 1 receptor
15. Carbohydrates and purines in underperfused hearts, protected by ischemic preconditioning
16. Adenosine alters glucose use during ischemia and reperfusion in isolated rat hearts
17. Antecedent ischemia reverses effects of adenosine on glycolysis and mechanical function of working hearts
18. Mechanisms of ischemic myocardial cell damage assessed by phosphorus-31 nuclear magnetic resonance
19. Protective effects of adenosine in the perfused rat heart: Changes in metabolism and intracellular ion homeostasis
20. Adenosine and preconditioning in the rat heart
21. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts
22. Extracellular adenosine levels and cellular energy metabolism in ischemically preconditioned rat heart
23. Ischemic preconditioning: Bioenergetic and metabolic changes and the role of endogenous adenosine
24. Does preconditioning act by glycogen depletion in the isolated rat heart?
25. 1 receptor mechanism
26. Pretreatment of human myocardium with adenosine during open heart surgery
27. Preconditioning of human myocardium with adenosine during coronary angioplasty
28. The cardioprotective effects of ischemic 'preconditioning' are not mediated by adenosine receptors in rat hearts
29. Repetitive acidosis protects the ischemic heart: Implications for mechanisms in preconditioned hearts
30. Glycogen depletion contributes to ischemic preconditioning in the rat heart in vivo
31. Turnover of adenosine in plasma of human and dog blood
32. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium
33. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode
34. Cardiovascular purinoceptors
35. Concentration-response relationships for adenosine agonists during preconditioning of rabbit cardiomyocytes
36. Effects of glycogen depletion on ischemic injury in isolated rat hearts: Insights into preconditioning
37. Role of preischemic glycogen depletion in the improvement of postischemic metabolic and contractile recovery of ischemia-preconditioned rat hearts
38. Mechanism of preconditioning. Ionic alterations
39. Effect of adenosine receptor blockade: Preventing protective preconditioning depends on time of initiation
40. 3 receptor mediated cardioprotection: Involvement in ischemic preconditioning
41. Adenosine slows ischaemic metabolism in canine myocardium in vitro: Relationship to ischaemic preconditioning
42. 3 adenosine receptor
43. Attenuated glycogenolysis reduces glycolytic catabolite accumulation during ischemia in preconditioned rat hearts
44. Loss of myocardial protection after preconditioning correlates with the time course of glycogen recovery within the preconditioned segment
45. Preconditioning the human myocardium
46. Ischaemic preconditioning: Present position and future directions
47. 3 adenosine receptor