X-ray structure of full-length annexin 1 and implications for membrane aggregation

Journal of Molecular Biology

Volumn 306, Issue 3, 2001, Pages 489-498

  Rosengarth, Anja ^a   Gerke, Volker ^b   Luecke, Hartmut ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Amphipathic helix; Annexin; Membrane aggregation; Membrane binding protein; X ray crystallography

Indexed keywords

CALCIUM; LIPOCORTIN 1; PHOSPHOLIPID BINDING PROTEIN;

ALPHA HELIX; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; GENETIC CONSERVATION; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

EID: 0035936691     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.4423     Document Type: Article

References (45)

1. Identification and purification of an adrenal medullary protein (synexin) that causes calcium-dependent aggregation of isolated chromaffin granules
2. Annexins and membrane dynamics
3. Three-dimensional structure of annexins
4. Annexins: The problem of assessing the biological role for a gene family of multifunctional calcium- and phospholipid-binding proteins
5. Annexin structure and membrane interactions: A molecular perspective
6. Ca(2+)-bridging mechanism and phospholipid head group recognition in the membrane-binding protein annexin 5
7. Annexin 1-mediated vesicular aggregation: Mechanism and role in human neutrophils
8. Regulation of the chromaffin granule aggregating activity of annexin 1 by phosphorylation
9. Annexin 1 interactions with human neutrophil specific granules: Fusogenicity and coaggregation with plasma membrane vesicles
10. Role of the amino-terminal domain in regulating interactions of annexin 1 with membranes: Effects of amino-terminal truncation and mutagenesis of the phosphorylation sites
11. Vesicle aggregation by annexin 1: Role of a secondary membrane binding site
12. Structural determinant of the vesicle aggregation activity of annexin 1
13. Aggregation of phospholipid vesicles by a chimera protein with the N-terminal of annexin 1 and the core of annexin 5
14. Binding to phosphatidyl serine membranes causes a conformational change in the concave face of annexin 1
15. Crystal structure of human annexin 1 at 2.5 Å resolution
16. Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin 1
17. The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes
18. Crystallization and preliminary X-ray analysis of full-length annexin 1 comprising the core and N-terminal domain
19. SOPMA: Significant improvements in protein secondary structure prediction by consensus prediction from multiple alignement
20. Location of tryptophans in membrane-bound annexins
21. Annexin binding to lipid assemblies
22. Characterization of lipocortin I and an immunologically unrelated 33-kDa protein as epidermal growth factor receptor/kinase substrates and phospholipase A2 inhibitors
23. 2+-dependent phospholipid binding and phosphorylation of lipocortin I
24. Annexin 1 is phosphorylated in the multivesicular body during the processing of the epidermal growth factor receptor
25. Crystal structure of the annexin 12 hexamer and implications for bilayer insertion
26. Annexin 12 E105K crystal structure: Identification of a pH-dependent switch for mutant hexamerization
27. Interaction of annexins with membranes: The N-terminus as a governing parameter as revealed with a chimeric annexin
28. Calcium-dependent binding of S100C to the N-terminal domain of annexin 1
29. Structural requirements for annexin 1-S100C complex-formation
30. Structural analysis of junctions formed between lipid membranes and several annexins by cryo-electron microscopy
31. cp37: Insights into the evolution of annexin 1 phosphorylation sites
32. A comparison of the energetics of annexin 1 and annexin 5
33. Processing of X-ray diffraction data collected in oscillation mode
34. Improved methods for building protein models in electron density maps and the location of errors in these models
35. Phase combination and cross validation in iterated density-modification calculations
36. Methods used in the structure determination of bovine mitochondrial F1 ATPase
37. Crystallography & NMR systems: A new software suite for macromolecular structure determination
38. PROCHECK: A program to check the stereochemical quality of protein structures
39. The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein
40. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
41. RASTER3D version 2.0: A program for photorealistic molecular graphics
42. SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules