Magnolol reduces myocardial ischemia/reperfusion injury via neutrophil inhibition in rats

European Journal of Pharmacology

Volumn 422, Issue 1-3, 2001, Pages 159-167

  Lee, Yen Mei ^a   Hsiao, George ^b   Chen, Huey Rue ^a   Chen, Yao Chang ^a   Sheu, Joen Rong ^b   Yen, Mao Hsiung ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antioxidant; Arrhythmia; Magnolol; Myocardial ischemia; Neutrophil

Indexed keywords

FORMYLMETHIONYLLEUCYLPHENYLALANINE; MAGNOLOL; MYELOPEROXIDASE; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; HEMODYNAMICS; HUMAN; HUMAN CELL; LEFT CORONARY ARTERY; MALE; MORTALITY; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; BIPHENYL COMPOUNDS; CHEMOTAXIS, LEUKOCYTE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEMODYNAMIC PROCESSES; LIGNANS; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NEUTROPHILS; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDES;

EID: 0035933410     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01069-X     Document Type: Article

References (42)

1. Inhibitors of nitric oxide synthase attenuate human neutrophil chemotaxis in vitro
2. Mitochondrial production of superoxide radical and hydrogen peroxide
3. Thromboxane and prostacyclin release from ischemic myocardium in relation to arrhythmias
4. The effects of ICS205-930, a 5-HT antagonist, on arrhythmias and catecholamine release during canine myocardial ischemia and reperfusion
5. Endogenous chemical mediators of ventricular arrhythmias in ischemic heart disease
6. Granulocytes cause reperfusion ventricular dysfunction after 15-minutes ischemia in the dog
7. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs
8. A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration
9. Hydrogen peroxide and superoxide modulate leukocyte adhesion molecule expression and leukocyte endothelial adhesion
10. Oxygen free radicals and cardiac reperfusion abnormalities
11. Effect of α-tocopherol on hypoxic-perfused and reoxygenated rabbit heart muscle
12. Lucigenin chemiluminescence in the assessment of neutrophil superoxide production
13. Magnolol inhibits leukotriene synthesis in rat basophilic leukemia-2H3 cells
14. Role of neutrophils in myocardial ischemia and reperfusion
15. Magnolol reduces infarct size and suppresses ventricular arrhythmia in rats subjected to coronary ligation
16. Oxidative injury to myocardial membrane: Direct modulation by endogenous α-tocopherol
17. Experimental myocardial infarction: 1. Method of coronary occlusion in small animals
18. Nitric oxide: An endogenous modulator of leukocyte adhesion
19. The oxygen free radical system: From equations through membrane-protein interactions to cardiovascular injury and protection
20. PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH
21. Antineutrophil and myocardial protecting actions of a novel nitric oxide donor after acute myocardial ischemia and reperfusion of dogs
22. Neutrophil depletion limited to reperfusion reduces myocardial infarct size after 90 minutes of ischemia. Evidence for neutrophil-mediated reperfusion injury
23. Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation
24. α-Tocopherol attenuates myocardial membrane related alterations resulting from ischemia and reperfusion
25. Oxygen-derived free radicals in postischemic tissue injury
26. Nitric oxide: Physiology, pathophysiology, and pharmacology
27. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium
28. Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size
29. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog
30. Hydrogen peroxide and hydroxyl radical mediation of activated leukocyte depression of cardiac sarcoplasmic reticulum. Participation of the cyclooxygenase pathway
31. Requirements for neutrophil products and L-arginine in ischemia-reperfusion injury
32. Interleukin-5 selectively enhances the chemotactic response of eosinophils obtained from normal but not eosinophilic subjects
33. Superoxide and hydrogen peroxide induce CD18-mediated adhesion in the postischemic heart
34. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion
35. Role of free radicals in catecholamine-induced cardiomyopathy
36. 2+-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb Magnolia officinalis, in rat thoracic aorta
37. The effects of L655240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia and reperfusion-induced cardiac arrhythmias
38. Anti-inflammatory and analgesic effects of magnolol
39. Free radicals in ischemic myocardial injury
40. The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat
41. Development of a novel method for determination of acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine acetyltransferase activity and its application to screening for acetyltransferase inhibitors, inhibition by magnolol and honokiol from magnoliae cortex
42. Direct measurement of free radical generation following reperfusion of ischemic myocardium