Uptake of pentamidine in Trypanosoma brucei brucei is mediated by the P2 adenosine transporter and at least one novel, unrelated transporter

Acta Tropica

Volumn 80, Issue 3, 2001, Pages 245-250

  De Koning, Harry P ^a   Jarvis, Simon M ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

Author keywords

Drug uptake; P2 transporter; Pentamidine; Trypanosoma brucei

Indexed keywords

ADENINE; ADENOSINE; ADENOSINE SENSITIVE PENTAMIDINE TRANSPORTER 1; ADENOSINE TRANSPORTER P2; DIAMIDINE DERIVATIVE; DRUG CARRIER; HYPOXANTHINE; IODINE 125; IODOPENTAMIDINE; LOW AFFINITY PENTAMIDINE TRANSPORTER 1; PENTAMIDINE; UNCLASSIFIED DRUG;

DRUG RESISTANCE; PEST CONTROL; TRYPANOSOMIASIS;

ANTIBIOTIC RESISTANCE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TRANSPORT; DRUG UPTAKE; IC 50; INHIBITION KINETICS; NONHUMAN; TRANSPORT KINETICS; TRYPANOSOMA BRUCEI;

ADENOSINE; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; DRUG RESISTANCE; MEMBRANE PROTEINS; NUCLEOSIDE TRANSPORT PROTEINS; PENTAMIDINE; RATS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

AFRICA;

TRYPANOSOMA; TRYPANOSOMA BRUCEI BRUCEI;

EID: 0035930394     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0001-706X(01)00177-2     Document Type: Article

References (19)

1. Resistance to clinical drugs in African trypanosomes
2. A diamidine-resistant Trypanosoma equiperdum clone contains a P2 purine transporter with reduced substrate affinity
3. Preparation and stability of a radioiodinated pentamidine isethionate analog
4. Arsenical-resistant trypanosomes lack an unusual adenosine transporter
5. Uptake of diamidine drugs by the P2 nucleoside transporter in melarsen-sensitive and -resistant Trypanosoma brucei brucei
6. A drug resistance determinant from Trypanosoma brucei
7. Pentamidine transport and sensitivity in brucei-group trypanosomes
8. Pentamidine transport in Trypanosoma brucei: Kinetics and specificity
9. Purine nucleobase transport in bloodstream forms of Trypanosoma brucei brucei is mediated by two novel transporters
10. Hypoxanthine uptake through a novel purine-selective nucleobase transporter in Trypanosoma brucei brucei procyclics is driven by protonmotive force
11. Purine transporters in bloodstream forms of T. b. brucei: Substrate recognition motifs and affinity for trypanocidal drugs
12. Characterization of a nucleoside-proton symporter in procyclic Trypanosoma brucei brucei
13. Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes
14. Characterisation of melarsen-resistant Trypanosoma brucei brucei with respect to cross-resistance to other drugs and trypanothione metabolism
15. Drug resistance in African trypanosomes
16. Separation of trypanosomes from the blood of infected rats and mice by anion-exchangers
17. Therapeutic failure of melarsoprol among patients treated for late stage T. b. gambiense human trypanosomiasis in Uganda
18. A nucleoside transporter from Trypanosoma brucei involved in drug resistance
19. The treatment of human African trypanosomiasis