Structural changes in the neck linker of kinesin explain the load dependence of the motor's mechanical cycle

Journal of Theoretical Biology

Volumn 211, Issue 2, 2001, Pages 143-157

  Mogilner, A ^a   Fisher, A J ^a   Baskin, R J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; KINESIN; NUCLEOTIDE;

PROTEIN;

ARTICLE; DISSOCIATION; FORCE; HYDROLYSIS; KINETICS; MECHANICS; MICROTUBULE; MODEL; PRIORITY JOURNAL; PROTEIN STRUCTURE; VELOCITY;

EID: 0035928490     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2001.2336     Document Type: Article

References (28)

1. Bead movement by single kinesin molecule with optical tweezers
2. The load dependence of kinesin's mechanical cycle
3. Kinesin takes one 8-nm step for each ATP that it hydrolyzes
4. The kinesin walk: A dynamic model with elastically coupled heads
5. Motor protein mechanics: A stochastic model with minimal mechanochemical coupling
6. A macroscopic description of biomolecular transport
7. The force exerted by a molecular motor
8. Simple mechanochemistry describes the dynamics of kinesin molecules
9. Alternating site mechanism of the kinesin ATPase
10. The road less traveled: Emerging principles of kinesin motor utilization
11. Evidence for alternating head Catalysis by kinesin during microtubule-stimulated ATP hydrolysis
12. The mechanochemistry of molecular motors
13. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility
14. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
15. Cellular motions and thermal fluctuations: The Brownian ratchet
16. Coordinated hydrolysis explains the mechanical behavior of kinesin
17. Kinesin follows the microtubule's protofilament axis
18. A structural change in the kinesin motor protein that drives motility
19. X-ray structure of motor and neck domains from rat brain kinesin
20. Force production by single kinesin motors
21. Direct observation of kinesin stepping by optical trapping interferometry
22. Force and velocity measured for single kinesin molecules
23. Fluctuation analysis of motor protein movement and single enzyme kinetics
24. Direct observation of single kinesin molecules moving along microtubules
25. The design plan for kinesin motors
26. Single kinesin molecules studied with a molecular force clamp