12-Hydroxyeicosatetraenoic acid potentiates angiotensin II-induced pressor response in rats

European Journal of Pharmacology

Volumn 418, Issue 1-2, 2001, Pages

  Takai, Shinji ^a   Jin, Denan ^a   Kirimura, Kazuyoshi ^a   Fujimoto, Yohko ^a   Miyazaki, Mizuo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

12 Hydroxyeicosatetraenoic acid; Angiotensin II; Hypertension

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ANGIOTENSIN; HYDROXYICOSATETRAENOIC ACID;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASOCONSTRICTION;

12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; ANGIOTENSIN II; ANIMALS; BLOOD PRESSURE; HYPERTENSION; MALE; RATS; TIME FACTORS;

EID: 0035917597     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00935-9     Document Type: Article

References (5)

1. Inhibition of lipoxygenase pathway reduces blood pressure in renovascular hypertensive rats
2. 12-Lipoxygenase products modulate calcium signals in vascular smooth muscle cells
3. Elevated 12-lipoxygenase activity in the spontaneously hypertensive rat
4. The lipoxygenase inhibitor phenidone is a potent hypotensive agent in the spontaneously hypertensive rat
5. 12-Hydroxyeicosatetraenoic acid directly potentiates angiotensin II-induced vascular contraction