Late mitotic failure in mice lacking Sak, a polo-like kinase

Current Biology

Volumn 11, Issue 6, 2001, Pages 441-446

  Hudson, J W ^a   Kozarova, A ^a   Cheung, P ^a   Macmillan, J C ^a   Swallow, C J ^a   Cross, J C ^b   Dennis, J W ^a,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; MAMMALIA;

EID: 0035916794     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00117-8     Document Type: Article

References (27)

1. Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles
2. Polo-like kinases: A team that plays throughout mitosis
3. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage
4. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint
5. Control of the DNA damage checkpoint by Chk1 and Rad53 protein kinases through distinct mechanisms
6. Polo-like kinase-1 is a target of the DNA damage checkpoint
7. Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation
8. Constitutive expression of murine Sak-a suppresses cell growth and induces multinucleation
9. Plk is a functional homolog of Saccharomyces cerevisiae Cdc5, and elevated Plk activity induces multiple septation structures
10. Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions
11. Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila
12. Identification of an early-growth-response gene encoding a novel putative protein kinase
13. Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk
14. 2 cells
15. Sak kinase gene structure and transcriptional regulation
16. DNA damage-induced activation of p53 by the checkpoint kinase Chk2
17. Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation
18. Temporal and spatial control of cyclin B1 destruction in metaphase
19. CDK1 inactivation regulates anaphase spindle dynamics and cytokinesis in vivo
20. Regulation of gene expression at the beginning of mammalian development
21. Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1
22. Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function
23. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
24. fizzy-dependent pathway in the early Xenopus cell cycle
25. The polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae
26. Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation
27. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles