Further evidence for the rodent bone marrow micronucleus assay acting as a sensitive predictor of the possible germ cell mutagenicity of chemicals

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 473, Issue 2, 2001, Pages 259-261

  Tinwell, H ^a   Brinkworth, M H ^b   Ashby, J ^a  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MUTAGEN; CORN OIL; CYCLOPHOSPHAMIDE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BONE MARROW EXAMINATION; CHEMICAL MUTAGENESIS; CONTROLLED STUDY; DIAGNOSTIC VALUE; DOMINANT LETHAL MUTANT; DOSE RESPONSE; GERM CELL; MALE; MICRONUCLEUS TEST; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; SHORT SURVEY;

ANIMALIA; RODENTIA; ZEA MAYS;

EID: 0035916423     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(00)00131-7     Document Type: Article

References (10)

1. Association of cyclophosphamide-induced male-mediated, foetal abnormalities with reduced paternal germ-cell apoptosis
2. Comparison of somatic and germ cell models for cytogenetic screening
3. The prospects for a simplified and internationally harmonised approach to the detection of possible human carcinogens and mutagens
4. The present lack of evidence for unique rodent germ cell mutagens
5. Selecting chemicals and assays for assessing mammalian germ cell mutagenicity
6. The performance of short-term tests in identifying potential germ cell mutagens: A qualitative and quantitative analysis
7. Concomitant observations of UDS in the liver and micronuclei in the bone marrow of rats exposed to cyclophosphamide or 2-acetylaminofluorene
8. Activity of DMBA, DMH and CP in triple- and single-dose rodent bone marrow micronucleus assays
9. Statistical methods for the dominant lethal assay