Cell type-specific expression and promoter activity of human endogenous retroviral long terminal repeats

Virology

Volumn 279, Issue 1, 2001, Pages 280-291

  Schön, Ulrike ^a   Seifarth, Wolfgang ^b   Baust, Corinna ^b   Hohenadl, Christine ^a,b   Erfle, Volker ^a   Leib Mösch, Christine ^a,b  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cell type specific promoters; HERV pol expression array.; HERV promoter activity; Human endogenous retrovirus; LTR; Luciferase expression vector

Indexed keywords

DNA DIRECTED DNA POLYMERASE BETA; LUCIFERASE;

ADAPTATION; ARTICLE; CELL SPECIFICITY; CONTROLLED STUDY; EPIDERMIS CELL; EXPRESSION VECTOR; GENE EXPRESSION; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KERATINOCYTE; KIDNEY CELL; LIVER CELL; LONG TERMINAL REPEAT; LUNG FIBROBLAST; LYMPHOCYTE; MOLECULAR CLONING; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PANCREAS CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; REGULATOR GENE; REPORTER GENE; RETROVIRUS; SCREENING TEST; VIRUS EXPRESSION; VIRUS PARTICLE;

HUMAN ENDOGENOUS RETROVIRUS; HUMAN ENDOGENOUS RETROVIRUS H; HUMAN ENDOGENOUS RETROVIRUS W; HUMAN ENDOGENOUS RETROVIRUSES; UNIDENTIFIED RETROVIRUS; VECTORS;

EID: 0035915999     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.2000.0712     Document Type: Article

References (55)

1. Demethylation of ERV3, an endogenous retrovirus regulating the Kruppel-related zinc finger gene H-plk, in several human cell lines arrested during early monocyte development
2. Comparative analyses of LTRs of the ERV-H family of primate-specific retrovirus-like elements isolated from marmoset, African green monkey, and man
3. HERV-K-T47D-related long terminal repeats mediate polyadenylation of cellular transcripts
4. Cloning of a new murine endogenous retrovirus, MuERV-L, with strong similarity to the human HERV-L element and with a gag coding sequence closely related to the Fv1 restriction gene
5. Molecular characterization and placentar expression of HERV-W, a new human endogenous retrovirus family
6. High-efficiency transformation of mammalian cells by plasmid DNA
7. Isolation of novel human endogenous retrovirus-like elements with foamy virus-related pol sequence
8. The long terminal repeats of the HERV-H human endogenous retrovirus contain binding sites for transcriptional regulation by the Myb protein
9. Characterization and genomic mapping of the ZNF80 locus: Expression of this zinc-finger gene is driven by a solitary LTR of ERV9 endogenous retroviral family
10. Functional heterogeneity of a large family of human LTR-like promoters and enhancers
11. Splicing of a human endogenous retrovirus to a novel phospholipase A2 related gene
12. A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta
13. Recent evolutionary expansion of a subfamily of RTVL-H human endogenous retrovirus-like elements
14. PCR and reverse dot hybridization for the detection of endogenous retroviral transcripts
15. Transcriptional activation of endogenous retroviral sequences in human epidermal keratinocytes by UVB irradiation
16. Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1
17. Activator protein 1 activity is involved in the regulation of the cell type-specific expression from the proximal promoter of the human profilaggrin gene
18. The keratinocyte-specific Epstein-Barr virus ED-L2 promoter is regulated by phorbol 12-myristate 13-acetate through two cis-regulatory elements containing E-box and Kruppel-like factor motifs
19. Members of the RTVL-H family of human endogenous retrovirus-like elements are expressed in placenta
20. Repeats in genomic DNA: Mining and meaning
21. The long terminal repeat of an endogenous retrovirus induces alternative splicing and encodes an additional carboxy-terminal sequence in the human leptin receptor
22. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Kruppel
23. Molecular cloning and characterization of MSRV-related sequences associated with retrovirus-like particles
24. Intergenic splicing between a HERV-H endogenous retrovirus and two adjacent human genes
25. A human endogenous retrovirus suppresses translation of an associated fusion transcript, PLA2L
26. Genomic distribution and transcription of solitary HERV-K LTRs
27. Evolution and biological significance of human retroelements
28. Sp1 activates and inhibits transcription from separate elements in the proximal promoter of the human adenine nucleotide translocase 2 (ANT2) gene
29. The viruses in all of us: Characteristics and biological significance of human endogenous retrovirus sequences
30. Expression of the smooth muscle myosin heavy chain gene is regulated by a negative-acting GC-rich element located between two positive-acting serum response factor-binding elements
31. Polyadenylation function and sequence variability of the long terminal repeats of the human endogenous retrovirus-like family RTVL-H
32. The structure and function of retroviral long terminal repeats
33. Characterization of novel reverse transcriptase encoding human endogenous retroviral sequences similar to type A and type B retroviruses: Differential transcription in normal human tissues
34. Expression of human endogenous retroviral sequences in peripheral blood mononuclear cells of healthy individuals
35. Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis
36. Gain of Sp1 sites and loss of repressor sequences associated with a young, transcriptionally active subset of HERV-H endogenous long terminal repeats
37. Structural and functional analysis of the promoter of the murine V gamma 1.1 T cell receptor gene
38. Our retroviral heritage
39. Sp1 and Sp3 regulate transcriptional activity of the facilitative glucose transporter isoform-3 gene in mammalian neuroblasts and trophoblasts
40. Nucleotide sequence of a full-length human endogenous retroviral segment
41. Expression of the human amylase genes: Recent origin of a salivary amylase promoter from an actin pseudogene
42. Human trophoblast and choriocarcinoma expression of the growth factor pleiotrophin attributable to germ-line insertion of an endogenous retrovirus
43. Structure and phylogenetic analysis of an endogenous retrovirus inserted into the human growth factor gene pleiotrophin
44. Proviral structure, chromosomal location, and expression of HERV-K-T47D, a novel human endogenous retrovirus derived from T47D particles
45. Rapid identification of all known retroviral reverse transcriptase sequences with a novel versatile detection assay
46. Retrovirus-like particles released from the human breast cancer cell line T47-D display type B- and C-related endogenous retroviral sequences
47. Increased binding of Sp1 to the gamma-globin gene promoter upon site-specific cytosine methylation
48. The promoter activity of long terminal repeats of the HERV-H family of human retrovirus-like elements is critically dependent on Sp1 family proteins interacting with a GC/GT box located immediately 3′ to the TATA box
49. Distinctive termini characterize two families of human endogenous retroviral sequences
50. The Sp-family of transcription factors
51. Common protein-binding sites in the 5′-flanking regions of human genes for cytochrome c1 and ubiquinone-binding protein
52. Endogenous retroviral sequences are required for tissue-specific expression of a human salivary amylase gene
53. Autonomous expression of RTVL-H endogenous retrovirus-like elements in human cells
54. Endogenous retroviruses